TABLE 2

Association of rs10500331 and rs12924838 with BMI or obesity in the populations described in Table 1

Population samplenrs10500331 (C/T)*rs12924838 (G/A)*
AF (T)PZAF (A)PZ
Full-heritage Pima Indian GWAS4130.498.1 × 10−53.940.503.0 × 10−43.61
Full-heritage Pima Indian population3,2340.491.9 × 10−75.200.503.3 × 10−64.65
Full-heritage Pima Indian population nonoverlapping with GWAS2,8430.491.9 × 10−54.280.504.2 × 10−54.10
French adult case/control subjects1,4260.130.980.0250.270.032.20
French children case/control subjects1,3920.130.96-0.060.270.900.13
German school children case/control subjects9980.120.800.26NDNDND
Old Order Amish1,1490.110.800.260.290.121.56
All Europeans4,9650.810.240.022.25
  • P values were determined using the additive model.

  • *Bold allele is defined as the risk allele (associated with higher BMI) based on the Pima GWAS data. Z scores are calculated from the one-sided P value for the alternate hypothesis that the association is in the same direction as that observed in the Pima GWAS.

  • †AF, allele frequency.

  • ‡Combined analysis for all Europeans was performed by combining the P values by Stouffer's method (i.e., combining the Z scores). LD between the two variants; Pima Indians D′ = 0.95, r2 = 0.95 and Caucasians D′ = 0.83, r2 = 0.25. ND indicates not determined.