TABLE 3

Association of A2BP1 variants with BMI in the full-heritage Pima Indians, mixed-heritage Native Americans, full + mixed-heritage combined, and all samples (Native Americans + Caucasians)

VariantM/mmAFFull-heritage Pima Indians (n = 3,234) Mean BMI (kg/m2)mAFMixed-heritage Native Americans (n = 2,531) Mean BMI (kg/m2)Full + mixed (n = 5,765) PAll samples§ (n = 10,730) P
M/MM/mm/mPM/MM/mm/mP
rs9302818*G/C0.4334.0 ± 8.033.6 ± 7.932.4 ± 7.75.5 × 10−60.4833.4 ± 8.632.5 ± 7.932.5 ± 8.00.750.0008ND
rs10500331*C/T0.4932.6 ± 7.833.6 ± 7.934.4 ± 8.21.9 × 10−70.4532.4 ± 8.132.8 ± 8.233.0 ± 8.60.900.00,0070.02
rs8052357*A/G0.2534.0 ± 7.933.0 ± 7.932.4 ± 7.91.0 × 10−50.2732.8 ± 8.132.5 ± 8.133.0 ± 7.60.500.0001ND
rs12924838*G/A0.5032.8 ± 7.833.7 ± 7.834.7 ± 8.23.3 × 10−60.4832.8 ± 8.232.8 ± 8.232.5 ± 8.60.260.0060.0009
rs1946127*T/C0.2434.0 ± 8.033.0 ± 7.832.8 ± 8.17.2 × 10−40.2633.0 ± 8.232.6 ± 8.331.3 ± 7.50.390.002ND
rs4786847A/G0.3133.4 ± 8.033.7 ± 7.734.3 ± 8.40.110.2732.0 ± 7.933.1 ± 8.334.7 ± 8.40.020.0080.0002
  • M, major allele; m, minor allele; mAF, minor allele frequency.

  • *Variants displaying the strongest association with BMI in the full-heritage Pima Indians.

  • †Variant with the strongest association with severe obesity in the French adult case/control subjects GWAS.

  • P values were calculated by using a mixed model (see methods).

  • §All samples include all of the subjects listed in Table 1.

  • ‖Data for the German school children case/control subjects was not available for variants rs12924838 and rs4786847. ND indicates not determined.