TABLE 2

Association of individual increased risk variants with prospective risk of stroke

VariantModelHR (95% CI)*P
IL-6GG/GC genotype1.2 (0.6–1.9)0.626
    Smoking (ever)0.9 (0.4–4.3)0.683
MCP-1GG genotype1.4 (0.9–2.0)0.102
    Smoking (ever)1.0 (0.4–2.1)0.857
ICAM-1EE genotype1.2 (0.8–2.0)0.365
    Smoking (ever)2.6 (1.2–6.0)0.022
sel-ERR genotype2.0 (0.5–8.0)0.346
    Smoking (ever)NA**NA
MMP35A5A genotype1.5 (1.0–2.2)0.075
    Smoking (ever)1.6 (0.7–3.7)0.273
  • *All models adjusted for age at study recruitment and sex.

  • **Zero individuals in at least one cell. NA, not available.