TABLE 2

HLA class I allele frequencies in 3,506 chromosomes from 1,753 type 1 diabetic probands and 1,585 affected family-based control chromosomes

AlleleType 1 diabetes (n)AFBAC (n)P
A*010117.7 (621)16.1 (256)0.214
A*01020.1 (4)0 (0)0.179
A*01030 (0)0.1 (2)0.035
A*020130.6 (1,074)27.6 (438)0.069
A*02020.2 (8)0 (0)0.057
A*02052.1 (73)1.2 (19)0.030
A*02060.3 (9)0.2 (3)0.646
A*02110 (1)0 (0)0.501
A*02200 (0)0.1 (1)0.137
A*02340 (0)0.1 (1)0.137
A*02350 (0)0.1 (1)0.137
A*030111.9 (417)13.1 (207)0.271
A*03020.5 (16)0.3 (4)0.282
A*03050 (0)0.1 (1)0.137
A*11013.4 (119)6.9 (109)5.E-08
A*11050 (0)0.1 (1)0.137
A*23011.2 (43)1.8 (29)0.094
A*24010 (0)0.1 (1)0.137
A*240211.3 (396)7.8 (123)2.E-04
A*24030.3 (10)0.1 (1)0.114
A*25012.3 (80)2.6 (42)0.432
A*26012.6 (90)2.8 (44)0.671
A*26070 (0)0.1 (1)0.137
A*26080.1 (2)0 (0)0.342
A*29010.3 (12)0.4 (6)0.840
A*29022.3 (80)3.4 (54)0.022
A*30010.7 (25)1.1 (17)0.191
A*30023.3 (117)1.7 (27)0.001
A*30040.1 (2)0.1 (1)0.934
A*30100 (1)0 (0)0.501
A*31012.1 (74)1.9 (30)0.614
A*32012.1 (73)4.2 (67)2.E-05
A*32040 (0)0.1 (1)0.137
A*33010.8 (27)1 (16)0.390
A*33030.4 (14)0.3 (5)0.650
A*34020.2 (6)0.1 (1)0.336
A*36010 (1)0.1 (2)0.184
A*66010.1 (3)0.6 (10)4.E-04
A*66020.1 (2)0 (0)0.342
A*68012.6 (91)2.7 (43)0.811
A*68020.4 (14)1.3 (20)5.E-04
A*69010 (0)0.1 (1)0.137
A*74010 (0)0.1 (1)0.137
A*80010 (1)0 (0)0.501
B*07027 (244)14.7 (233)7.E-17
B*07040 (0)0.1 (1)0.137
B*07050.7 (26)0.3 (4)0.035
B*07070 (0)0.1 (1)0.137
B*080121 (735)10.9 (173)4.E-15
B*08090 (0)0.1 (1)0.137
B*13021.8 (64)2 (31)0.752
B*14010.2 (8)0.6 (9)0.052
B*14021.7 (60)2.6 (41)0.040
B*150112.3 (432)4.5 (71)2.E-16
B*15020.1 (2)0 (0)0.342
B*15030.1 (5)0.1 (1)0.444
B*15070.1 (3)0 (0)0.244
B*15080 (1)0 (0)0.501
B*15090.1 (2)0.1 (1)0.934
B*15100.1 (4)0 (0)0.179
B*15150 (1)0 (0)0.501
B*15160 (1)0.1 (1)0.564
B*15170.4 (15)0.3 (4)0.343
B*15180.2 (6)0.3 (5)0.305
B*15240.1 (3)0 (0)0.244
B*15250 (0)0.1 (1)0.137
B*15370 (1)0 (0)0.501
B*15710 (0)0.1 (1)0.137
B*15730 (0)0.1 (1)0.137
B*180110.2 (357)6.3 (100)2.E-05
B*18120 (1)0 (0)0.501
B*27010 (0)0.1 (1)0.137
B*27020.3 (9)0.4 (6)0.458
B*27033.2 (113)3.1 (49)0.807
B*27070 (1)0.1 (2)0.184
B*35013.6 (126)6.3 (100)2.E-05
B*35020.3 (12)1.5 (23)1.E-05
B*35031.6 (56)1.5 (23)0.698
B*35080.3 (12)0.5 (8)0.392
B*35120 (0)0.1 (1)0.137
B*37010.7 (23)1 (16)0.182
B*38011.8 (63)2.5 (40)0.091
B*39011.2 (42)1.2 (19)0.998
B*39063.2 (112)0.4 (7)3.E-09
B*40015.6 (198)4.4 (69)0.062
B*40020.6 (20)1.6 (25)4.E-04
B*40060.1 (3)0.2 (3)0.318
B*40090 (1)0 (0)0.501
B*40140 (0)0.1 (2)0.035
B*41011 (34)0.3 (4)0.006
B*41020.1 (2)0.4 (6)0.007
B*42010 (1)0 (0)0.501
B*42020 (0)0.1 (1)0.137
B*44026 (210)9 (143)1.E-04
B*44032 (69)5.7 (91)2.E-12
B*44040 (0)0.1 (1)0.137
B*44050.2 (7)0.1 (1)0.255
B*45010.5 (17)0.4 (7)0.835
B*47010.3 (10)0.4 (6)0.582
B*47020 (1)0 (0)0.501
B*48010.1 (2)0.1 (1)0.934
B*49012.2 (77)1.1 (17)0.006
B*50012.1 (75)1.2 (19)0.022
B*50020.1 (2)0.1 (1)0.934
B*51013 (104)4.2 (67)0.023
B*51020 (0)0.1 (1)0.137
B*51050 (0)0.1 (1)0.137
B*51070 (1)0.1 (1)0.564
B*51080.1 (4)0.1 (1)0.591
B*52010.3 (12)1.1 (18)0.001
B*53010.1 (5)0.5 (8)0.018
B*55010.9 (30)1.6 (26)0.013
B*56010.6 (20)0.6 (10)0.795
B*57010.5 (19)3.5 (56)4.E-16
B*57030 (1)0.3 (5)0.006
B*58010.9 (31)1.1 (18)0.397
B*73010.3 (9)0.1 (1)0.149
B*81010 (1)0 (0)0.501
C*01022 (69)3 (48)0.021
C*02023.9 (136)4.4 (69)0.435
C*02060 (1)0.1 (1)0.564
C*03020.3 (12)0.4 (7)0.591
C*03035.5 (194)3.9 (62)0.017
C*030413.5 (475)6.6 (105)1.E-11
C*03050.1 (3)0 (0)0.244
C*03140 (1)0 (0)0.501
C*04016 (212)11.6 (184)4.E-11
C*04030 (0)0.1 (1)0.137
C*050111.3 (397)9.5 (150)0.061
C*06025.9 (208)8.4 (133)0.002
C*06060 (1)0 (0)0.501
C*070125.7 (900)15 (238)1.E-13
C*070210.8 (378)15.6 (247)6.E-06
C*07041 (34)1.9 (30)0.007
C*08010.1 (5)0.1 (2)0.884
C*08021.9 (66)3.2 (50)0.005
C*12020.3 (12)1.1 (17)0.001
C*12035.7 (200)6.4 (102)0.322
C*14020.7 (25)1.2 (19)0.084
C*15021.4 (50)2 (32)0.123
C*15040.2 (8)0.1 (2)0.447
C*15050.8 (27)0.3 (5)0.058
C*16011.2 (43)3.8 (60)3.E-09
C*16020.5 (17)0.2 (3)0.119
C*16040.1 (4)0.4 (6)0.049
C*17010.8 (27)0.7 (11)0.771
C*18010 (1)0.1 (1)0.564
  • P values lower than 0.1 are shown in boldface type.