TABLE 3

HLA class I alleles significantly different from expected values when accounting for LD with DRB1-DQB1

AlleleType 1 diabetes observed (%)Type 1 diabetes expected (%)OR (95% CI)P
A*010117.721.90.77 (0.66–0.88)0.002
A*020130.624.71.35 (1.17–1.54)3.E-04
A*11013.46.20.53 (0.40–0.70)8.E-06
A*240211.47.01.71 (1.37–2.12)5.E-06
A*32012.13.80.54 (0.37–0.75)4.E-04
A*66010.10.60.16 (0.04–0.57)9.E-04
A*68020.41.20.34 (0.17–0.69)0.002
B*07027.011.40.58 (0.47–0.70)3.E-07
B*07050.70.23.42 (1.11–10.5)0.023
B*150112.39.41.36 (1.11–1.65)0.004
B*180110.25.22.05 (1.59–2.61)3.E-08
B*35013.64.90.72 (0.53–0.96)0.028
B*35020.31.20.29 (0.14–0.60)5.E-04
B*39063.20.310.31 (4.21–25.1)4.E-10
B*40020.51.20.45 (0.23–0.84)0.012
B*41011.00.24.49 (1.48–13.6)0.004
B*41020.10.30.19 (0.03–0.96)0.020
B*44031.94.50.42 (0.30–0.59)4.E-07
B*49012.20.92.6 (1.45–4.63)0.001
B*50012.11.02.27 (1.30–3.94)0.003
B*52010.30.90.37 (0.17–0.80)0.009
B*53010.10.40.33 (0.10–1.06)0.055
B*57010.52.80.19 (0.11–0.32)4.E-11
B*57030.00.30.11 (0.01–0.96)0.013
C*03035.53.81.48 (1.10–1.99)0.010
C*04016.09.30.63 (0.50–0.78)6.E-05
C*050111.37.61.56 (1.26–1.93)9.E-05
C*12020.30.90.39 (0.17–0.83)0.014
C*14020.71.40.52 (0.29–0.93)0.027
C*15050.80.32.78 (1.01–7.62)0.039
C*16011.23.00.39 (0.25–0.58)5.E-06
  • †Expected values calculated based on LD of class I alleles with DR-DQ–encoding loci in this population.