TABLE 5

Summary of statistically significant relative ORs on specific haplotypes for class I alleles

AlleleDR3DR4DR8DR1DR2NumberConsistent effect
A*01010.69 (0.59–0.78)0.75 (0.57–0.98)2Yes
A*02010.58 (0.38–0.89)
A*03011.47 (1.14–1.88)
A*1101X0.60 (0.38–0.91)
A*24021.69 (1.25–2.28)1.52 (1.15–2.01)3.31 (1.90–5.74)2.18 (1.51–3.14)4Yes
A*26010.65 (0.46–0.89)X
A*29022.22 (1.03–4.78)
A*31010.57 (0.41–0.79)
A*32010.57 (0.36–0.88)0.19 (0.04–0.89)X2Yes
A*6601X0.10 (0.01–0.98)
A*68010.62 (0.38–0.99)3.32 (1.14–9.64)4.83 (1.02–22.6)3No
B*08010.68 (0.62–0.74)
B*18011.58 (1.31–1.90)1.74 (1.19–2.53)2Yes
B*3501X4.79 (1.07–21.4)4.79 (1.07–21.4)2No
B*3503XX14.54 (2.66–79.3)
B*3801X0.70 (0.49–0.97)X
B*3901XX2.44 (1.01–5.88)
B*390611.56 (0.68–195.0)2.70 (1.16–6.29)14.03 (5.55–35.4)7.15 (3.89–13.1)14.54 (2.66–79.3)4Yes
B*40010.71 (0.56–0.88)
B*44020.34 (0.13–0.84)
B*44034.83 (1.12–20.6)0.5 (0.32–0.77)XX2No
B*4901X1.61 (1.01–2.53)XXX
B*50011.95 (1.22–3.11)XXX
B*51010.36 (0.13–0.96)
B*5301XXXX28.11 (1.75–449.0)
B*56010.10 (0.01–0.81)XXXX
C*01020.30 (0.11–0.77)
C*04014.82 (1.87–12.3)
C*05011.48 (1.21–1.81)0.29 (0.12–0.68)2No
C*06021.56 (1.09–2.21)X
C*07010.70 (0.60–0.80)0.26 (0.08–0.80)0.51 (0.28–0.92)3Yes
C*07021.31 (1.00–1.70)3.65 (2.42–5.48)1.94 (1.41–2.65)3Yes
C*1202X0.15 (0.03–0.61)XXX
C*1402X0.33 (0.11–0.92)X
C*15020.57 (0.37–0.87)X
C*1604X0.38 (0.15–0.90)
  • For each allele, the relative OR value represents a comparison of the DR haplotype carrying the allele to that DR haplotype carrying any class I allele. X = total n in contingency table ≤12.

  • †Although the confidence interval overlaps 1, this result, with relative OR of 11.56, has been included for comparison. Data for seven alleles that exhibit a consistent disease association on more than one haplotype are indicated in boldface type.