TABLE 3

Associations with HbA1C of 10 independent loci conditioned on levels of fasting or 2-h glucose

SNPNearest locusEffect/OtherFasting glucose2-h glucose
HbA1C (%) adjusted for sex, ageHbA1C (%) adjusted for glucose, sex, ageFasting glucose (mmol/l) adjusted for sex, ageHbA1C (%) adjusted for sex. ageHbA1C (%) adjusted for 2 h-glucose, sex, age2-h glucose (mmol/l) adjusted for sex, age
rs2779116SPTA1T/Cβ (SE)0.019 (0.004)0.017 (0.004)−0.001 (0.005)0.026 (0.008)0.029 (0.008)0.029 (0.037)
P2.4 × 1061.7 × 1060.9009.6 × 1042.9 × 1040.432
N20,70021,35921,5056,3946,3476,347
rs552976G6PC2 /ABCB11G/Aβ (SE)0.028 (0.004)0.013 (0.003)0.060 (0.005)0.029 (0.007)0.027 (0.007)−0.021 (0.034)
P4.5 × 10152.0 × 1056.3 × 10366.1 × 1051.4 × 1040.538
N23,49623,49623,6426,3936,3466,346
rs1800562HFEG/Aβ (SE)0.054 (0.007)0.048 (0.006)−0.008 (0.010)0.095 (0.016)0.096 (0.016)0.086 (0.073)
P3.1 × 10132.5 × 10140.4191.1 × 1091.1 × 1090.239
N23,50323,50323,6496,3896,3426,342
rs1799884GCKT/Cβ (SE)0.030 (0.005)0.018 (0.004)0.053 (0.0063)0.037 (0.010)0.039 (0.010)0.111 (0.046)
P5.6 × 10117.3 × 1064.7 × 10171.3 × 1046.2 × 1050.0143
N23,49723,49723,6436,3946,3476,347
rs4737009ANK1A/Gβ (SE)0.023 (0.004)0.017 (0.004)0.010 (0.006)0.023 (0.008)0.025 (0.008)−0.049 (0.038)
P3.2 × 1082.7 × 1060.0724.4 × 1032.3 × 1030.197
N21,35521,35521,5016,3906,3436,343
rs16926246HK1C/Tβ (SE)0.073 (0.007)0.069 (0.006)−0.013 (0.009)0.010 (0.017)0.097 (0.017)0.012 (0.092)
P4.8 × 10266.4 × 10300.1781.6 × 1091.3 × 1080.899
N22,40422,40422,5505,3015,2545,254
rs1387153MTNR1BT/Cβ (SE)0.027 (0.004)0.013 (0.004)0.056 (0.006)0.035 (0.008)0.032 (0.009)0.036 (0.040)
P1.9 × 10112.2 × 1041.8 × 10233.1 × 1051.5 × 1040.362
N20,16220,16220,3086,3946,3476,347
rs7998202ATP11A/TUBGCP3G/Aβ (SE)0.027 (0.006)0.023 (0.005)0.013 (0.008)0.041 (0.012)0.035 (0.012)−0.035 (0.054)
P3.4 × 1061.3 × 1050.1084.0 × 1042.6 × 1030.512
N21,35921,35921,5056,3946,3476,347
rs1046896FN3KT/Cβ (SE)0.030 (0.004)0.026 (0.003)0.005 (0.005)0.045 (0.008)0.043 (0.008)−0.011 (0.036)
P2.0 × 10161.0 × 10150.3433.0 × 1092.0 × 1080.753
N23,49623,49623,6426,3936,3466,346
rs855791TMPRSS6A/Gβ (SE)0.020 (0.004)0.019 (0.003)−0.006 (0.005)0.024 (0.008)0.022 (0.008)0.009 (0.036)
P6.7 × 1088.3 × 1090.2231.7 × 1036.1 × 1030.815
N23,50823,50823,6546,3946,3476,347
  • β (SE) is the per-effect allele increase in HbA1C (%) as in Table 2. For analyses conditional on fasting glucose, data were available for up to 23,654 samples from 15 cohorts (ARIC, BLSA, CROATIA, Fenland, FHS, DESIR, GENOMEUTWIN, Lolipop, NTR, ORCADES, SardiNIA, KORA F4, DGI, Sorbs and Health2000). For analyses conditional on 2-h glucose, data were available for only a smaller set of six cohorts totaling up to 6,394 samples (BLSA, Fenland, FHS, KORA F4, DGI and Sorbs). The SNP association with HbA1C after adjusting for fasting glucose is attenuated most at the G6PC2/ABCB11, GCK and MTNR1B loci. Associations at ANK1 are given for rs4737009, with the ANK1 SNP showing the strongest association with HbA1C.