TABLE 2

Substrate kinetics pre- and posttraining

ControlType 2 diabetes
PretrainingPosttrainingPretrainingPosttraining
Plasma insulin (mU/l)
    Basal18.1 ± 2.416.1 ± 2.1*16.4 ± 1.214.6 ± 0.8*
    Clamp112.5 ± 5.4112.1 ± 5.5107.6 ± 4.8103.1 ± 2.7
Plasma FFA (μmol/l)
    Basal479.0 ± 22.9454.9 ± 28.3519.4 ± 25.3500.1 ± 34.1
    Clamp84.7 ± 7.267.5 ± 6.9*107.1 ± 8.787.6 ± 8.7*
Rd glucose (μmol · kg−1 · min−1)
    Basal8.7 ± 0.78.3 ± 0.611.6 ± 0.7†9.9 ± 0.6*
    Clamp25.8 ± 2.326.7 ± 2.318.4 ± 1.4†21.0 ± 1.4*†
    Delta17.1 ± 2.418.4 ± 2.16.8 ± 1.4†11.1 ± 1.4*†
Endogenous glucose production (μmol · kg−1 · min−1)
    Basal8.7 ± 0.68.7 ± 0.610.3 ± 0.69.1 ± 0.7
    Clamp2.8 ± 0.81.0 ± 1.0*2.9 ± 0.51.4 ± 0.3*
    Delta−5.7 ± 1.1−7.2 ± 1.2−7.9 ± 0.6−7.7 ± 0.8
CHO oxidation (μmol · kg−1 · min−1)
    Basal6.5 ± 0.57.1 ± 0.58.1 ± 0.67.3 ± 0.4
    Clamp12.5 ± 0.813.0 ± 0.711.7 ± 0.813.2 ± 0.8
    Delta5.9 ± 0.75.9 ± 0.63.6 ± 0.8†5.9 ± 0.7*
Nonoxidative glucose disposal (μmol · kg−1 · min−1)
    Basal2.3 ± 0.71.1 ± 0.63.5 ± 0.92.6 ± 0.8
    Clamp13.5 ± 1.713.7 ± 2.36.7 ± 1.2†8.0 ± 1.2†
    Delta11.3 ± 1.912.6 ± 1.93.2 ± 1.4†5.3 ± 1.2†
Lipid oxidation (μmol · kg−1 · min−1)
    Basal1.08 ± 0.051.03 ± 0.051.08 ± 0.051.09 ± 0.05
    Clamp0.63 ± 0.040.55 ± 0.040.75 ± 0.04†0.59 ± 0.05*
    Delta−0.46 ± 0.05−0.48 ± 0.06−0.32 ± 0.06−0.49 ± 0.06*
  • Data are expressed as means ± SE.

  • *Posttraining significantly different from pretraining.

  • †Type 2 diabetic group data significantly different from control group data.