TABLE 1

Body weight and blood glucose of mice

Body Weight (g)P vs. controlNonfasted blood glucose (mg/dl)P vs. control
10–12 weeks of age
    Control24.8 ± 1.5149 ± 9
    LIRKO24.2 ± 1.7NS198 ± 40NS
    D2KO/LIRKO18.5 ± 1.4<0.01>600<0.000,001
    D2KO19.7 ± 1.40.024188 ± 220.042
25 weeks of age
    Control23.1 ± 0.9172 ± 5
    IRS1KO18.4 ± 1.10.012176 ± 9NS
    D2KO/IRS1KO13.5 ± 0.4<0.005390 ± 41<0.005
    D2KO21.2 ± 0.8NS253 ± 18<0.005
  • Data are means ± SE (n = 5–9 male mice). NS, nonsignificant.