TABLE 5

Proportion of difference in metabolic memory between adults and adolescents after 10 years of EDIC follow-up explained by DCCT and EDIC mean A1C

Model*Effectχ2PProportion explained (%)
Overall
    Unadjusted for A1CDCCT treatment group by age (adolescent vs. adult) interaction effect4.20.0385
    Adjusted for DCCT mean A1CDCCT treatment group by age (adolescent vs. adult) interaction effect0.90.344879
    Adjusted for DCCT-EDIC mean A1CDCCT treatment group by age (adolescent vs. adult) interaction effect0.60.441286
INT only§
    Unadjusted for A1CAge effect (adolescent vs. adult)5.90.0155
    Adjusted for DCCT mean A1CAge effect (adolescent vs. adult)0.40.507193
CON only§
    Unadjusted for A1CAge effect (adolescent vs. adult)0.00.8848
  • *All the models (unadjusted and adjusted) were from Weibull model after adjustment for all the risk factors in Table 3. A1C during DCCT or across DCCT and EDIC combined was further adjusted in the adjusted models.

  • †Proportion explained; see “Statistical analyses” section.

  • ‡The interaction term of DCCT treatment group and age (adolescent vs. adult) measures the difference in prolonged treatment effect (metabolic memory) between adults and adolescents.

  • §Model used was from the same Weibull model in Table 3 but constructed within the INT and CON group, respectively.

  • ‖Because there is no age (adolescent vs. adult) effect in the unadjusted model, there is no need to further adjust for A1C.