TABLE 3

Morphological and metabolic variable summaries by treatment category in ∼10-week-old fasted wild-type mice that received continuous subcutaneous infusion of either vehicle or leptin at a physiological dose

SalineGroupHighest leptin
All leptin*
n = 8n = 24n = 8P§P
Body mass (g)19.3 ± 1.019.4 ± 0.819.4 ± 0.60.810.77
LBM (g)16.0 ± 0.816.2 ± 0.716.3 ± 0.50.470.32
FM (g)1.6 ± 0.41.5 ± 0.41.4 ± 0.30.780.29
% Body fat8.0 ± 1.47.7 ± 1.96.9 ± 1.60.670.17
Leptin (ng/ml)0.3 ± 0.37.1 ± 4.511.9 ± 3.20.00020.00001
Activity (counts/min)55.4 ± 14.744.2 ± 16.240.4 ± 9.70.090.03
RER0.73 ± 0.0050.73 ± 0.0070.73 ± 0.0050.621.0
24-h mean EE (cal/min)6.43 ± 0.477.14 ± 0.537.37 ± 0.230.0020.0002
  • Data are means ± SD. n = 32.

  • *Group includes animals receiving 50, 100, and 200 ng leptin/h.

  • †Group includes animals receiving only 200 ng leptin/h.

  • §Significance of comparison between saline and all leptin-treated mice.

  • ‖Significance of comparison between saline and mice receiving 200 ng leptin/h.