TABLE 1

Consortia studying type 1 diabetes

ConsortiumFull name of consortiumConsortium activitiesConsortium website
T1DGCType 1 Diabetes Genetics ConsortiumT1DGC was established with the primary goal of organizing international efforts to identify genes that determine an individual's risk of type 1 diabetes (2).www.t1dgc.org
TEDDYThe Environmental Determinants of Diabetes in the YoungThe primary objective(s) of TEDDY is the identification of infectious agents, dietary factors, or other environmental exposures that are associated with increased risk of autoimmunity and type 1 diabetes (3).teddy.epi.usf.edu
nPODNetwork for Pancreatic Organ donors with DiabetesThe mission of nPOD is to characterize pancreata and related tissues from organ donors with type 1 diabetes or who are islet autoantibody positive and utilize the tissues to address key immunological, histological, viral, and metabolic questions related to how type 1 diabetes develops (4).www.jdrfnpod.org
SEARCHSearch for Diabetes in YouthSEARCH identifies cases of diabetes in children/youth <20 years of age in six geographically dispersed populations that encompass the ethnic diversity of the United States (5).www.searchfordiabetes.org
TrialNetType 1 Diabetes TrialNetTrialNet is an international network conducting studies that will improve the understanding of type 1 diabetes disease development and test interventions to interdict the type 1 diabetes disease process, particularly strategies for type 1 diabetes prevention (6).www.diabetestrialnet.org
ITNImmune Tolerance NetworkITN is an international consortium dedicated to the clinical evaluation of novel tolerogenic approaches for the treatment of autoimmune diseases (including type 1 diabetes), asthma, and allergic diseases, and the prevention of graft rejection (7).www.immunetolerance.org
TRIGRTrial to Reduce IDDM in the Genetically at RiskTRIGR is testing whether weaning to a casein hydrolysate formula during the first 6–8 months of life—in place of cow's milk-based formula—reduces the incidence of autoimmunity and type 1 diabetes in genetically susceptible newborn infants (8).trigr.epi.usf.edu/
ICRsIslet Cell Resource CentersICRs' goals are: 1) to provide high-quality islets for use in transplantation; 2) to optimize characterization of quality and effectiveness of islets transplanted into patients; and 3) to provide islets for basic science studies (9).icr.coh.org/
CITRCollaborative Islet Transplant RegistryCITR is expediting progress and promoting safety in islet transplantation through the collection, analysis, and communication of comprehensive and current data on all such transplants performed in North America (10).www.citregistry.org
CITClinical Islet Transplantation ConsortiumThis consortium is implementing a program of clinical studies, accompanied by mechanistic studies, in islet transplantation with or without accompanying kidney transplantation, for the treatment of type 1 diabetes (11).www.isletstudy.org
DirecNetDiabetes Research in Children NetworkDirecNet is investigating the potential use of glucose monitoring technology and its impact on the management of type 1 diabetes in children (12).public.direc.net/
EDICEpidemiology of Diabetes Interventions and ComplicationsEDIC is studying the clinical course and risk factors associated with long-term complications of type 1 diabetes in the Diabetes Control and Complications Trial (DCCT) cohort (13).www.bsc.gwu.edu/bsc/studies/edic.html