TABLE 3

Effect of diabetes and insulin therapy on representative proteins annotated to oxidative phosphorylation and mitochondrial dysfunction

SymbolProtein descriptionFoldControl% Change
DiabeticDiabetic + insulin
ATP5C1ATP synthase, F1 complex, γ0.901.29*143
ATP5DATP synthase, F1 complex, Δ subunit0.69*0.92133
ATP5F1ATP synthase, F0 complex, subunit B10.921.31*142
ATP5IATP synthase, F0 complex, subunit E0.75*0.81108
COX2Cytochrome c oxidase subunit 20.821.06129
COX4I1Cytochrome c oxidase subunit IV isoform 10.71*0.89125
COX5ACytochrome c oxidase subunit Va0.831.28*154
CPT1ACarnitine palmitoyltransferase 1A (liver)0.51*0.77172
CYCSCytochrome c, somatic0.56*0.9160
HSD17B10Hydroxysteroid (17-β) dehydrogenase 100.71*1.14160
ND4NADH dehydrogenase, subunit 4 (complex I)0.43*0.56*130
NDUFA10NADH dehydrogenase 1 α subcomplex 10§0.73*0.79108
NDUFA13NADH dehydrogenase 1 α subcomplex, 130.35*0.59*168
NDUFB10NADH dehydrogenase 1 β subcomplex, 100.941.4*148
NDUFS1NADH dehydrogenase Fe-S protein 10.780.91116
NDUFS2NADH dehydrogenase Fe-S protein 20.48*0.54113
NDUFS3NADH dehydrogenase Fe-S protein 30.64*0.84131
NDUFS8NADH dehydrogenase Fe-S protein 80.911.34*147
PRDX3Peroxiredoxin 30.871.26*145
PRDX5Peroxiredoxin 50.74*0.86116
SOD2Superoxide dismutase 2, mitochondrial0.73*1.08148
UQCRC1Ubiquinol-cytochrome c reductase I0.871.26*145
  • Values shown are the mean and the asterisk (*) indicates proteins that showed a significant change in expression. Percent change represents effect of insulin treatment on the protein expression ratio measured from diabetic rats. Please see online supplementary Table 1 for more complete information.

  • ¶Confirming references (8,16);

  • §Confirming reference (29).