TABLE 1

Effect of HFD on fasting body weight, plasma leptin, stomach expression of ghrelin and Mboat4, and colonic expression of Pyy and glucagon

Weeks of diet
481216
ControlHFDControlHFDControlHFDControlHFD
Body weight (g)24.5 ± 1.627.9 ± 0.728.0 ± 1.232.7 ± 1.228.4 ± 0.434.3 ± 1.129.9 ± 1.035.5 ± 1.1
P < 0.05P < 0.01P < 0.001
Leptin (ng/mL)0.6 ± 0.13.2 ± 1.00.8 ± 0.23.1 ± 1.01.2 ± 0.58.3 ± 2.71.0 ± 0.18.5 ± 2.1
P < 0.05P < 0.05P < 0.01
Stomach
ghrelin (AU)1.1 ± 0.11.2 ± 0.11.0 ± 0.11.1 ± 0.11.3 ± 0.11.3 ± 0.11.4 ± 0.11.3 ± 0.1
Stomach
Mboat4 (AU)0.7 ± 0.50.7 ± 0.10.7 ± 0.10.6 ± 0.10.7 ± 0.10.6 ± 0.10.8 ± 0.10.7 ± 0.1
Colonic Pyy (AU)1.1 ± 0.11.2 ± 0.11.1 ± 0.11.2 ± 0.11.2 ± 0.11.0 ± 0.11.0 ± 0.11.2 ± 0.1
Colonic
glucagon (AU)1.0 ± 0.11.2 ± 0.11.2 ± 0.11.2 ± 0.11.2 ± 0.11.0 ± 0.11.0 ± 0.11.2 ± 0.1
  • Data are means ± SE. Body weights and fasting expression of stomach ghrelin and Mboat4 and colonic Pyy and glucagon after 4, 8, 12, and 16 weeks' exposure to control diet or HFD.