TABLE 3

Steady-state concentrations and metabolic clearance rates for GLP-1 and GIP infused alone or in combination

IncretinSteady-state concentration (pmol/L)Significance (P value)Metabolic clearance rate (mL · kg−1 · min−1)Significance (P value)
GLP-10.360.50
 Alone155 ± 2415.4 ± 7.4
 With GIP132 ± 1210.0 ± 1.0
GIP0.690.34
 Alone533 ± 238.0 ± 0.6
 With GLP-1526 ± 338.0 ± 0.6
  • Data are means ± SE. The analysis is based on total GLP-1 and GIP concentrations (research design and methods). Metabolic clearance rates were calculated by dividing infusion rates (pmol · kg−1 · min−1) by steady-state concentrations (60–360 min) (pmol/L) (Fig. 2).