Table 4

Previously reported T2D-susceptibility loci associated with T2D-related quantitative traits (P < 8.77 × 10−4) in GUARDIAN

LocusSNP (effect allele)AIRgHOMABSIHOMAIRFasting glucoseFasting insulinDISG
β ± SDPADDβ ± SDPADDβ ± SDPADDβ ± SDPADDβ ± SDPADDβ ± SDPADDβ ± SDPADDβ ± SDPADD
GCKRrs780094 (A)0.50 ± 0.530.100.05 ± 0.100.220.03 ± 0.060.120.00 ± 0.070.98−0.37 ± 0.530.18−0.01 ± 0.100.750.71 ± 0.740.0800.12 ± 0.055.38 × 10−6
G6PC2rs560887 (A)−0.95 ± 0.720.0110.28 ± 0.131.25 × 10−4−0.03 ± 0.080.700.12 ± 0.100.031−0.83 ± 0.720.0330.18 ± 0.130.013−1.98 ± 1.002.30 × 10−4−0.04 ± 0.060.15
ADCY5rs11708067 (G)1.07 ± 0.592.97 × 10−40.13 ± 0.110.0300.07 ± 0.070.430.05 ± 0.080.23−0.43 ± 0.570.180.08 ± 0.100.131.86 ± 0.811.57 × 10−50.06 ± 0.050.042
IGF2BP2rs4402960 (A)−0.74 ± 0.570.0180.01 ± 0.100.84−0.07 ± 0.060.470.04 ± 0.080.430.39 ± 0.560.180.04 ± 0.100.52−1.60 ± 0.804.01 × 10−4−0.08 ± 0.050.0042
IGF2BP2rs1470579 (C)−0.71 ± 0.570.0230.03 ± 0.100.61−0.07 ± 0.060.480.04 ± 0.080.340.32 ± 0.560.240.05 ± 0.100.44−1.58 ± 0.794.93 × 10−4−0.08 ± 0.050.0091
CDKAL1rs7754840 (C)−1.32 ± 0.551.07 × 10−5−0.15 ± 0.100.0100.11 ± 0.060.0013−0.09 ± 0.080.0340.35 ± 0.510.21−0.11 ± 0.100.033−0.55 ± 0.760.15−0.03 ± 0.050.15
CDKAL1rs7756992 (G)−1.12 ± 0.552.49 × 10−4−0.14 ± 0.100.0150.10 ± 0.060.017−0.07 ± 0.080.110.45 ± 0.540.13−0.09 ± 0.100.084−0.36 ± 0.770.30−0.04 ± 0.050.12
CDKAL1rs9368222 (A)−1.46 ± 0.584.74 × 10−6−0.15 ± 0.100.0140.11 ± 0.060.0090−0.09 ± 0.080.0480.41 ± 0.570.19−0.10 ± 0.100.070−0.87 ± 0.810.032−0.07 ± 0.050.010
TCF7L2rs7903146 (A)−1.12 ± 0.595.10 × 10−4−0.09 ± 0.110.16−0.03 ± 0.060.69−0.01 ± 0.080.870.62 ± 0.580.057−0.01 ± 0.110.85−1.50 ± 0.820.0011−0.01 ± 0.050.72
KCNQ1rs2237892 (A)0.86 ± 0.586.13 × 10−3−0.11 ± 0.100.0900.01 ± 0.070.93−0.09 ± 0.080.031−0.18 ± 0.570.62−0.12 ± 0.100.0181.58 ± 0.813.14 × 10−40.01 ± 0.050.88
KCNQ1rs163184 (C)−1.00 ± 0.502.70 × 10−40.03 ± 0.090.750.04 ± 0.060.440.04 ± 0.070.220.33 ± 0.490.310.05 ± 0.090.29−1.10 ± 0.690.00370.00 ± 0.040.97
KCNQ1rs2237895 (C)−1.06 ± 0.501.35 × 10−4−0.01 ± 0.090.740.04 ± 0.060.240.02 ± 0.070.490.38 ± 0.500.220.02 ± 0.090.53−1.11 ± 0.700.0034−0.01 ± 0.050.79
ARAP1/CENTD2rs1552224 (C)1.94 ± 1.038.53 × 10−40.19 ± 0.190.11−0.07 ± 0.110.390.10 ± 0.140.20−0.24 ± 1.040.600.12 ± 0.190.262.14 ± 1.430.0094−0.03 ± 0.090.59
MTNR1Brs1387153 (A)−2.06 ± 0.601.38 × 10−9−0.15 ± 0.110.020−0.13 ± 0.070.089−0.02 ± 0.080.631.13 ± 0.594.73 × 10−4−0.07 ± 0.110.30−3.26 ± 0.831.40 × 10−11−0.10 ± 0.056.85 × 10−4
MTNR1Brs10830963 (G)−2.31 ± 0.609.46 × 10−12−0.15 ± 0.110.021−0.13 ± 0.070.160.03 ± 0.080.581.60 ± 0.591.50 × 10−60.00 ± 0.111.00−3.71 ± 0.831.11 × 10−14−0.12 ± 0.051.09 × 10−4
  • Data are means ± SE unless otherwise indicated. P values < 8.77 × 10−4 are shown in boldface type.