Table 3

Geometric means of insulin sensitivity and secretion indicators according to categories of obesity-related indices

Category of obesity-related indices
Q1 
(<25%)Q2 
(25 to <50%)Q3 
(50 to <75%)Q4-1 
(75 to <90%)Q4-2 
(90 to <95%)Q4-3 
(≥95%)Ptrend
BMI (kg/m2)17.0–22.322.4–24.224.2–26.426.4–28.228.2–30.730.8–37.4
 n 50 50 50 30 10 10
 SI (10−4 dL/kg/min per μU/mL)
  Model 114.33 ± 1.999.33 ± 1.306.92 ± 0.965.62 ± 1.014.61 ± 1.433.25 ± 1.01< 0.01
  Model 212.14 ± 1.729.07 ± 1.246.87 ± 0.936.33 ± 1.125.43 ± 1.643.32 ± 1.00< 0.01
 Φs (10−9/min)
  Model 145.08 ± 5.0947.20 ± 5.3340.81 ± 4.6147.09 ± 6.8761.21 ± 15.4734.83 ± 8.800.85
  Model 242.50 ± 4.9744.64 ± 5.0439.90 ± 4.4551.01 ± 7.4362.24 ± 15.4934.37 ± 8.520.70
  Model 342.08 ± 4.8543.49 ± 4.8540.89 ± 4.5151.97 ± 7.4663.37 ± 15.5335.62 ± 8.700.50
 Φd (10−9)
  Model 1349.06 ± 65.71438.26 ± 82.50487.63 ± 91.79541.09 ± 131.50650.03 ± 273.62380.33 ± 160.090.20
  Model 2350.56 ± 70.76409.18 ± 79.77466.81 ± 89.91538.08 ± 135.35588.41 ± 252.79386.81 ± 165.530.24
  Model 3348.01 ± 70.24401.36 ± 78.50475.34 ± 91.82545.51 ± 137.29596.27 ± 256.10397.17 ± 170.110.20
Waist circumference (cm)59.5–78.079.0–84.085.0–91.091.5–97.097.5–99.5100.0–119.0
 n 47 54 49 31 9 10
 SI (10−4 dL/kg/min per μU/mL)
  Model 116.33 ± 2.229.22 ± 1.177.85 ± 1.044.25 ± 0.714.92 ± 1.532.49 ± 0.73< 0.01
  Model 213.79 ± 2.149.17 ± 1.238.19 ± 1.105.00 ± 0.875.27 ± 1.642.75 ± 0.81< 0.01
 Φs (10−9/min)
  Model 150.42 ± 5.8845.83 ± 4.9944.44 ± 5.0841.80 ± 6.0042.93 ± 11.4431.59 ± 7.990.10
  Model 241.37 ± 5.4544.44 ± 5.0344.14 ± 5.0248.13 ± 7.1249.41 ± 13.0733.25 ± 8.310.96
  Model 340.88 ± 5.3043.69 ± 4.8744.80 ± 5.0248.96 ± 7.1450.70 ± 13.2134.15 ± 8.400.86
 Φd (10−9)
  Model 1479.02 ± 91.30283.03 ± 50.33545.94 ± 101.91603.64 ± 141.66691.21 ± 301.05339.48 ± 140.270.30
  Model 2420.73 ± 92.49258.23 ± 48.78533.42 ± 101.21596.67 ± 147.42781.66 ± 345.12328.09 ± 136.890.19
  Model 3416.64 ± 91.49254.67 ± 48.11539.85 ± 102.38605.12 ± 149.40798.29 ± 352.12335.30 ± 139.780.17
Body fat (%)*14.8–25.526.3–32.332.4–36.937.3–41.741.9–43.544.1–51.3
 n 49 51 46 32 10 9
 SI (10−4 dL/kg/min per μU/mL)
  Model 112.73 ± 1.876.73 ± 0.978.35 ± 1.276.57 ± 1.207.99 ± 2.604.87 ± 1.670.01
  Model 215.88 ± 2.287.14 ± 0.925.84 ± 0.904.45 ± 0.815.47 ± 1.673.59 ± 1.16< 0.01
 Φs (10−9/min)
  Model 145.29 ± 5.0937.82 ± 4.1648.24 ± 5.5949.65 ± 6.9029.72 ± 7.3979.95 ± 20.950.24
  Model 250.57 ± 6.1038.88 ± 4.1941.48 ± 5.3544.78 ± 6.8327.66 ± 7.1074.89 ± 20.330.89
  Model 349.05 ± 5.8639.55 ± 4.2141.32 ± 5.2546.58 ± 7.0428.51 ± 7.2277.70 ± 20.820.67
 Φd (10−9)
  Model 1339.36 ± 64.57503.17 ± 93.84478.05 ± 93.87435.58 ± 102.55350.12 ± 147.46902.97 ± 400.870.19
  Model 2343.37 ± 72.64510.96 ± 96.54425.44 ± 96.12421.20 ± 112.67356.70 ± 160.49878.76 ± 418.160.36
  Model 3334.90 ± 71.13518.29 ± 98.02424.03 ± 95.71435.07 ± 116.87365.76 ± 164.57905.87 ± 431.230.30
  • Data are mean ± SD unless otherwise indicated. Model 1: crude. Model 2: adjusted for age, sex, cigarette smoking, alcohol consumption, physical activity, total cholesterol, and triglycerides. Model 3: further adjusted for insulin sensitivity.

  • *Sample size for analyses of percent body fat was 197.