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Most-Read Articles during January 2012 -- updated monthly

Most-read rankings are recalculated at the beginning of the month and are based on full-text and pdf views.

  1. Pathophysiology:
    • Mary C. Gannon and
    • Frank Q. Nuttall
    Effect of a High-Protein, Low-Carbohydrate Diet on Blood Glucose Control in People With Type 2 Diabetes Diabetes September 2004 53:2375-2382; doi:10.2337/diabetes.53.9.2375
  2. Banting Lecture:
    • Barbara E. Corkey
    Banting Lecture 2011: Hyperinsulinemia: Cause or Consequence? Diabetes January 2012 61:4-13; doi:10.2337/db11-1483
    Free Article
  3. Banting Lecture 2004:
    • Michael Brownlee
    The Pathobiology of Diabetic Complications: A Unifying Mechanism Diabetes June 2005 54:1615-1625; doi:10.2337/diabetes.54.6.1615
  4. Section II: Type 1-Related Forms of Diabetes:
    • Gunnar Stenström,
    • Anders Gottsäter,
    • Ekaterine Bakhtadze,
    • Bo Berger,
    • and Göran Sundkvist
    Latent Autoimmune Diabetes in Adults: Definition, Prevalence, β-Cell Function, and Treatment Diabetes December 2005 54:S68-S72; doi:10.2337/diabetes.54.suppl_2.S68
  5. Perspectives in Diabetes:
    • Fredrik Karpe,
    • Julian R. Dickmann,
    • and Keith N. Frayn
    Fatty Acids, Obesity, and Insulin Resistance: Time for a Reevaluation Diabetes October 2011 60:2441-2449; doi:10.2337/db11-0425
  6. Perspectives in Diabetes:
    • Edwin A.M. Gale
    The Rise of Childhood Type 1 Diabetes in the 20th Century Diabetes December 2002 51:3353-3361; doi:10.2337/diabetes.51.12.3353
  7. Metabolism and Signal Transduction:
    • Emma M. Bingham,
    • David Hopkins,
    • Diarmuid Smith,
    • Andrew Pernet,
    • William Hallett,
    • Laurence Reed,
    • Paul K. Marsden,
    • and Stephanie A. Amiel
    The Role of Insulin in Human Brain Glucose Metabolism: An 18Fluoro-Deoxyglucose Positron Emission Tomography Study Diabetes December 2002 51:3384-3390; doi:10.2337/diabetes.51.12.3384
  8. Section I: Insulin Resistance-Beta-Cell Connection in Type 2 Diabetes:
    • Gordon C. Weir and
    • Susan Bonner-Weir
    Five Stages of Evolving Beta-Cell Dysfunction During Progression to Diabetes Diabetes December 2004 53:S16-S21; doi:10.2337/diabetes.53.suppl_3.S16
  9. Perspectives in Diabetes:
    • Marc T. Hamilton,
    • Deborah G. Hamilton,
    • and Theodore W. Zderic
    Role of Low Energy Expenditure and Sitting in Obesity, Metabolic Syndrome, Type 2 Diabetes, and Cardiovascular Disease Diabetes November 2007 56:2655-2667; published ahead of print September 7, 2007, doi:10.2337/db07-0882
  10. Complications:
    • Charles M. Alexander,
    • Pamela B. Landsman,
    • Steven M. Teutsch,
    • and Steven M. Haffner
    NCEP-Defined Metabolic Syndrome, Diabetes, and Prevalence of Coronary Heart Disease Among NHANES III Participants Age 50 Years and Older Diabetes May 2003 52:1210-1214; doi:10.2337/diabetes.52.5.1210
  11. Original Article - Obesity Studies:
    • Iain T.H. Au-Yong,
    • Natasha Thorn,
    • Rakesh Ganatra,
    • Alan C. Perkins,
    • and Michael E. Symonds
    Brown Adipose Tissue and Seasonal Variation in Humans Diabetes November 2009 58:2583-2587; published ahead of print August 20, 2009, doi:10.2337/db09-0833
  12. Section IV: Polygenic Disease and Environment:
    • Mikael Knip,
    • Riitta Veijola,
    • Suvi M. Virtanen,
    • Heikki Hyöty,
    • Outi Vaarala,
    • and Hans K. Åkerblom
    Environmental Triggers and Determinants of Type 1 Diabetes Diabetes December 2005 54:S125-S136; doi:10.2337/diabetes.54.suppl_2.S125
  13. Section III: Mitochondria, Beta-Cell Function, and Type 2 Diabetes:
    • Sophie Rousset,
    • Marie-Clotilde Alves-Guerra,
    • Julien Mozo,
    • Bruno Miroux,
    • Anne-Marie Cassard-Doulcier,
    • Frédéric Bouillaud,
    • and Daniel Ricquier
    The Biology of Mitochondrial Uncoupling Proteins Diabetes February 2004 53:S130-S135; doi:10.2337/diabetes.53.2007.S130
  14. Section III: Inflammation and β-Cell Death:
    • Marc Y. Donath,
    • Jan A. Ehses,
    • Kathrin Maedler,
    • Desiree M. Schumann,
    • Helga Ellingsgaard,
    • Elisabeth Eppler,
    • and Manfred Reinecke
    Mechanisms of β-Cell Death in Type 2 Diabetes Diabetes December 2005 54:S108-S113; doi:10.2337/diabetes.54.suppl_2.S108
  15. Editorial:
    • K. Sreekumaran Nair
    Changing of the Guards Diabetes January 2012 61:1-3; doi:10.2337/db11-1490
    Free Article
  16. Original Article - Obesity Studies:
    • Shiho Fujisaka,
    • Isao Usui,
    • Agussalim Bukhari,
    • Masashi Ikutani,
    • Takeshi Oya,
    • Yukiko Kanatani,
    • Koichi Tsuneyama,
    • Yoshinori Nagai,
    • Kiyoshi Takatsu,
    • Masaharu Urakaze,
    • Masashi Kobayashi,
    • and Kazuyuki Tobe
    Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice Diabetes November 2009 58:2574-2582; published ahead of print August 18, 2009, doi:10.2337/db08-1475
  17. Pathophysiology:
    • Barbora Vozarova,
    • Christian Weyer,
    • Robert S. Lindsay,
    • Richard E. Pratley,
    • Clifton Bogardus,
    • and P. Antonio Tataranni
    High White Blood Cell Count Is Associated With a Worsening of Insulin Sensitivity and Predicts the Development of Type 2 Diabetes Diabetes February 2002 51:455-461; doi:10.2337/diabetes.51.2.455
  18. Section V: The Incretin Pathway:
    • Maria Sörhede Winzell and
    • Bo Ahrén
    The High-Fat Diet–Fed Mouse: A Model for Studying Mechanisms and Treatment of Impaired Glucose Tolerance and Type 2 Diabetes Diabetes December 2004 53:S215-S219; doi:10.2337/diabetes.53.suppl_3.S215
  19. Pharmacology and Therapeutics:
    • Songping Han,
    • Deborah L. Hagan,
    • Joseph R. Taylor,
    • Li Xin,
    • Wei Meng,
    • Scott A. Biller,
    • John R. Wetterau,
    • William N. Washburn,
    • and Jean M. Whaley
    Dapagliflozin, a Selective SGLT2 Inhibitor, Improves Glucose Homeostasis in Normal and Diabetic Rats Diabetes June 2008 57:1723-1729; published ahead of print March 20, 2008, doi:10.2337/db07-1472
  20. Islet Studies:
    • Alexandra E. Butler,
    • Juliette Janson,
    • Susan Bonner-Weir,
    • Robert Ritzel,
    • Robert A. Rizza,
    • and Peter C. Butler
    β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes Diabetes January 2003 52:102-110; doi:10.2337/diabetes.52.1.102
  21. Perspectives in Diabetes:
    • Phillip Kantharidis,
    • Bo Wang,
    • Rosemarie M. Carew,
    • and Hui Yao Lan
    Diabetes Complications: The MicroRNA Perspective Diabetes July 2011 60:1832-1837; doi:10.2337/db11-0082
  22. Section III: Inflammation and β-Cell Death:
    • Miriam Cnop,
    • Nils Welsh,
    • Jean-Christophe Jonas,
    • Anne Jörns,
    • Sigurd Lenzen,
    • and Decio L. Eizirik
    Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities Diabetes December 2005 54:S97-S107; doi:10.2337/diabetes.54.suppl_2.S97
  23. Banting Lecture:
    • Ralph A. DeFronzo
    From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus Diabetes April 2009 58:773-795; doi:10.2337/db09-9028
  24. Perspectives in Diabetes:
    • Selene L. Fernandez-Valverde,
    • Ryan J. Taft,
    • and John S. Mattick
    MicroRNAs in β-Cell Biology, Insulin Resistance, Diabetes and Its Complications Diabetes July 2011 60:1825-1831; doi:10.2337/db11-0171
  25. Obesity Studies:
    • Patrice D. Cani,
    • Jacques Amar,
    • Miguel Angel Iglesias,
    • Marjorie Poggi,
    • Claude Knauf,
    • Delphine Bastelica,
    • Audrey M. Neyrinck,
    • Francesca Fava,
    • Kieran M. Tuohy,
    • Chantal Chabo,
    • Aurélie Waget,
    • Evelyne Delmée,
    • Béatrice Cousin,
    • Thierry Sulpice,
    • Bernard Chamontin,
    • Jean Ferrières,
    • Jean-François Tanti,
    • Glenn R. Gibson,
    • Louis Casteilla,
    • Nathalie M. Delzenne,
    • Marie Christine Alessi,
    • and Rémy Burcelin
    Metabolic Endotoxemia Initiates Obesity and Insulin Resistance Diabetes July 2007 56:1761-1772; published ahead of print April 24, 2007, doi:10.2337/db06-1491
  26. Metabolism:
    • Patrice D. Cani,
    • Rodrigo Bibiloni,
    • Claude Knauf,
    • Aurélie Waget,
    • Audrey M. Neyrinck,
    • Nathalie M. Delzenne,
    • and Rémy Burcelin
    Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice Diabetes June 2008 57:1470-1481; published ahead of print February 27, 2008, doi:10.2337/db07-1403
  27. Section III: Mitochondria, Beta-Cell Function, and Type 2 Diabetes:
    • J. Antonie Maassen,
    • Leen. M. ‘t Hart,
    • Einar van Essen,
    • Rob J. Heine,
    • Giel Nijpels,
    • Roshan S. Jahangir Tafrechi,
    • Anton K. Raap,
    • George M.C. Janssen,
    • and Herman H.P.J. Lemkes
    Mitochondrial Diabetes: Molecular Mechanisms and Clinical Presentation Diabetes February 2004 53:S103-S109; doi:10.2337/diabetes.53.2007.S103
  28. Genetics:
    • Rona J. Strawbridge,
    • Josée Dupuis,
    • Inga Prokopenko,
    • Adam Barker,
    • Emma Ahlqvist,
    • Denis Rybin,
    • John R. Petrie,
    • Mary E. Travers,
    • Nabila Bouatia-Naji,
    • Antigone S. Dimas,
    • Alexandra Nica,
    • Eleanor Wheeler,
    • Han Chen,
    • Benjamin F. Voight,
    • Jalal Taneera,
    • Stavroula Kanoni,
    • John F. Peden,
    • Fabiola Turrini,
    • Stefan Gustafsson,
    • Carina Zabena,
    • Peter Almgren,
    • David J.P. Barker,
    • Daniel Barnes,
    • Elaine M. Dennison,
    • Johan G. Eriksson,
    • Per Eriksson,
    • Elodie Eury,
    • Lasse Folkersen,
    • Caroline S. Fox,
    • Timothy M. Frayling,
    • Anuj Goel,
    • Harvest F. Gu,
    • Momoko Horikoshi,
    • Bo Isomaa,
    • Anne U. Jackson,
    • Karen A. Jameson,
    • Eero Kajantie,
    • Julie Kerr-Conte,
    • Teemu Kuulasmaa,
    • Johanna Kuusisto,
    • Ruth J.F. Loos,
    • Jian'an Luan,
    • Konstantinos Makrilakis,
    • Alisa K. Manning,
    • María Teresa Martínez-Larrad,
    • Narisu Narisu,
    • Maria Nastase Mannila,
    • John Öhrvik,
    • Clive Osmond,
    • Laura Pascoe,
    • Felicity Payne,
    • Avan A. Sayer,
    • Bengt Sennblad,
    • Angela Silveira,
    • Alena Stančáková,
    • Kathy Stirrups,
    • Amy J. Swift,
    • Ann-Christine Syvänen,
    • Tiinamaija Tuomi,
    • Ferdinand M. van 't Hooft,
    • Mark Walker,
    • Michael N. Weedon,
    • Weijia Xie,
    • Björn Zethelius,
    • the DIAGRAM Consortium,
    • the GIANT Consortium,
    • the MuTHER Consortium,
    • the CARDIoGRAM Consortium,
    • the C4D Consortium,
    • Halit Ongen,
    • Anders Mälarstig,
    • Jemma C. Hopewell,
    • Danish Saleheen,
    • John Chambers,
    • Sarah Parish,
    • John Danesh,
    • Jaspal Kooner,
    • Claes-Göran Östenson,
    • Lars Lind,
    • Cyrus C. Cooper,
    • Manuel Serrano-Ríos,
    • Ele Ferrannini,
    • Tom J. Forsen,
    • Robert Clarke,
    • Maria Grazia Franzosi,
    • Udo Seedorf,
    • Hugh Watkins,
    • Philippe Froguel,
    • Paul Johnson,
    • Panos Deloukas,
    • Francis S. Collins,
    • Markku Laakso,
    • Emmanouil T. Dermitzakis,
    • Michael Boehnke,
    • Mark I. McCarthy,
    • Nicholas J. Wareham,
    • Leif Groop,
    • François Pattou,
    • Anna L. Gloyn,
    • George V. Dedoussis,
    • Valeriya Lyssenko,
    • James B. Meigs,
    • Inês Barroso,
    • Richard M. Watanabe,
    • Erik Ingelsson,
    • Claudia Langenberg,
    • Anders Hamsten,
    • and Jose C. Florez
    Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes Diabetes October 2011 60:2624-2634; published ahead of print August 26, 2011, doi:10.2337/db11-0415
  29. Section III: The Gastrointestinal Connection:
    • Gareth E. Lim and
    • Patricia L. Brubaker
    Glucagon-Like Peptide 1 Secretion by the L-Cell: The View From Within Diabetes December 2006 55:S70-S77; doi:10.2337/db06-S020
  30. Perspectives in Diabetes:
    • Charlotte Ling and
    • Leif Groop
    Epigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes Diabetes December 2009 58:2718-2725; doi:10.2337/db09-1003
  31. Perspectives in Diabetes:
    • R. Paul Robertson,
    • Jamie Harmon,
    • Phuong Oanh Tran,
    • Yoshito Tanaka,
    • and Hiroki Takahashi
    Glucose Toxicity in β-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection Diabetes March 2003 52:581-587; doi:10.2337/diabetes.52.3.581
  32. Obesity Studies:
    • Daniela Lamers,
    • Susanne Famulla,
    • Nina Wronkowitz,
    • Sonja Hartwig,
    • Stefan Lehr,
    • D. Margriet Ouwens,
    • Kristin Eckardt,
    • Jean M. Kaufman,
    • Mikael Ryden,
    • Stefan Müller,
    • Franz-Georg Hanisch,
    • Johannes Ruige,
    • Peter Arner,
    • Henrike Sell,
    • and Juergen Eckel
    Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome Diabetes July 2011 60:1917-1925; published ahead of print May 18, 2011, doi:10.2337/db10-1707
  33. Perspectives in Diabetes:
    • Reza Abdi,
    • Paolo Fiorina,
    • Chaker N. Adra,
    • Mark Atkinson,
    • and Mohamed H. Sayegh
    Immunomodulation by Mesenchymal Stem Cells: A Potential Therapeutic Strategy for Type 1 Diabetes Diabetes July 2008 57:1759-1767; doi:10.2337/db08-0180
  34. Section I: Aspects of Pathophysiology:
    • Peter Achenbach,
    • Ezio Bonifacio,
    • Kerstin Koczwara,
    • and Anette-G. Ziegler
    Natural History of Type 1 Diabetes Diabetes December 2005 54:S25-S31; doi:10.2337/diabetes.54.suppl_2.S25
  35. Pathophysiology:
    • Esben S. Buhl,
    • Niels Jessen,
    • Rasmus Pold,
    • Thomas Ledet,
    • Allan Flyvbjerg,
    • Steen B. Pedersen,
    • Oluf Pedersen,
    • Ole Schmitz,
    • and Sten Lund
    Long-Term AICAR Administration Reduces Metabolic Disturbances and Lowers Blood Pressure in Rats Displaying Features of the Insulin Resistance Syndrome Diabetes July 2002 51:2199-2206; doi:10.2337/diabetes.51.7.2199
  36. Section 6: Pusatile and Phasic Insulin Release in Normal and Diabetic Men:
    • Errol B. Marliss and
    • Mladen Vranic
    Intense Exercise Has Unique Effects on Both Insulin Release and Its Roles in Glucoregulation: Implications for Diabetes Diabetes February 2002 51:S271-S283; doi:10.2337/diabetes.51.2007.S271
  37. Obesity Studies:
    • Carey N. Lumeng,
    • Stephanie M. DeYoung,
    • Jennifer L. Bodzin,
    • and Alan R. Saltiel
    Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity Diabetes January 2007 56:16-23; doi:10.2337/db06-1076
  38. Obesity Studies:
    • Yun Sok Lee,
    • Pingping Li,
    • Jin Young Huh,
    • In Jae Hwang,
    • Min Lu,
    • Jong In Kim,
    • Mira Ham,
    • Saswata Talukdar,
    • Ai Chen,
    • Wendell J. Lu,
    • Guatam K. Bandyopadhyay,
    • Reto Schwendener,
    • Jerrold Olefsky,
    • and Jae Bum Kim
    Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet–Induced Insulin Resistance Diabetes October 2011 60:2474-2483; published ahead of print September 12, 2011, doi:10.2337/db11-0194
  39. Commentaries:
    • Morgan D. Fullerton and
    • Gregory R. Steinberg
    SIRT1 Takes a Backseat to AMPK in the Regulation of Insulin Sensitivity by Resveratrol Diabetes March 2010 59:551-553; doi:10.2337/db09-1732
  40. Metabolism:
    • Da Young Oh,
    • Hidetaka Morinaga,
    • Saswata Talukdar,
    • Eun Ju Bae,
    • and Jerrold M. Olefsky
    Increased Macrophage Migration Into Adipose Tissue in Obese Mice Diabetes February 2012 61:346-354; published ahead of print December 21, 2011, doi:10.2337/db11-0860
  41. Perspectives in Diabetes:
    • Maigan A. Hulme,
    • Clive H. Wasserfall,
    • Mark A. Atkinson,
    • and Todd M. Brusko
    Central Role for Interleukin-2 in Type 1 Diabetes Diabetes January 2012 61:14-22; doi:10.2337/db11-1213
  42. Obesity Studies:
    • Changtao Jiang,
    • Aijuan Qu,
    • Tsutomu Matsubara,
    • Tatyana Chanturiya,
    • William Jou,
    • Oksana Gavrilova,
    • Yatrik M. Shah,
    • and Frank J. Gonzalez
    Disruption of Hypoxia-Inducible Factor 1 in Adipocytes Improves Insulin Sensitivity and Decreases Adiposity in High-Fat Diet–Fed Mice Diabetes October 2011 60:2484-2495; published ahead of print August 26, 2011, doi:10.2337/db11-0174
  43. Rapid Publication:
    • Matthias Tschöp,
    • Christian Weyer,
    • P. Antonio Tataranni,
    • Viswanath Devanarayan,
    • Eric Ravussin,
    • and Mark L. Heiman
    Circulating Ghrelin Levels Are Decreased in Human Obesity Diabetes April 2001 50:707-709; doi:10.2337/diabetes.50.4.707
  44. Signal Transduction:
    • Gwen Tolhurst,
    • Helen Heffron,
    • Yu Shan Lam,
    • Helen E. Parker,
    • Abdella M. Habib,
    • Eleftheria Diakogiannaki,
    • Jennifer Cameron,
    • Johannes Grosse,
    • Frank Reimann,
    • and Fiona M. Gribble
    Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein–Coupled Receptor FFAR2 Diabetes February 2012 61:364-371; published ahead of print December 21, 2011, doi:10.2337/db11-1019
  45. Pharmacology & Therapeutics:
    • Yun S. Lee,
    • Woo S. Kim,
    • Kang H. Kim,
    • Myung J. Yoon,
    • Hye J. Cho,
    • Yun Shen,
    • Ji-Ming Ye,
    • Chul H. Lee,
    • Won K. Oh,
    • Chul T. Kim,
    • Cordula Hohnen-Behrens,
    • Alison Gosby,
    • Edward W. Kraegen,
    • David E. James,
    • and Jae B. Kim
    Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States Diabetes August 2006 55:2256-2264; doi:10.2337/db06-0006
  46. Section IV: Lipid Modulators of Islet Function:
    • Peter J. Havel
    Update on Adipocyte Hormones: Regulation of Energy Balance and Carbohydrate/Lipid Metabolism Diabetes February 2004 53:S143-S151; doi:10.2337/diabetes.53.2007.S143
  47. Posters: Clinical Diabetes/Therapeutics Diabetes July 2011 60:A235-A352; doi:10.2337/db11-868-1281
  48. Introduction:
    • Katsutaro Morino,
    • Kitt Falk Petersen,
    • and Gerald I. Shulman
    Molecular Mechanisms of Insulin Resistance in Humans and Their Potential Links With Mitochondrial Dysfunction Diabetes December 2006 55:S9-S15; doi:10.2337/db06-S002
  49. Obesity Study:
    • William A. Banks,
    • Alan B. Coon,
    • Sandra M. Robinson,
    • Asif Moinuddin,
    • Jessica M. Shultz,
    • Ryota Nakaoke,
    • and John E. Morley
    Triglycerides Induce Leptin Resistance at the Blood-Brain Barrier Diabetes May 2004 53:1253-1260; doi:10.2337/diabetes.53.5.1253
  50. Metabolism:
    • Yong Deuk Kim,
    • Keun-Gyu Park,
    • Yong-Soo Lee,
    • Yun-Yong Park,
    • Don-Kyu Kim,
    • Balachandar Nedumaran,
    • Won Gu Jang,
    • Won-Jea Cho,
    • Joohun Ha,
    • In-Kyu Lee,
    • Chul-Ho Lee,
    • and Hueng-Sik Choi
    Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase–Dependent Regulation of the Orphan Nuclear Receptor SHP Diabetes February 2008 57:306-314; published ahead of print October 1, 2007, doi:10.2337/db07-0381

Last updated 02/07/2012 20:22:15

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