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Most-Read Articles during April 2013 -- updated monthly

Most-read rankings are recalculated at the beginning of the month and are based on full-text and pdf views.

  1. Editorial:
    • James A. Levine
    Poverty and Obesity in the U.S. Diabetes November 2011 60:2667-2668; doi:10.2337/db11-1118
    Free Article
  2. Perspectives in Diabetes:
    • John C Lawrence, Jr and
    • Peter J Roach
    New Insights Into the Role and Mechanism of Glycogen Synthase Activation by Insulin Diabetes April 1997 46:541-547; doi:10.2337/diab.46.4.541
  3. Pathophysiology:
    • Mary C. Gannon and
    • Frank Q. Nuttall
    Effect of a High-Protein, Low-Carbohydrate Diet on Blood Glucose Control in People With Type 2 Diabetes Diabetes September 2004 53:2375-2382; doi:10.2337/diabetes.53.9.2375
  4. Original Research:
    • Cheng-Che E. Lan,
    • Ching-Shuang Wu,
    • Shu-Mei Huang,
    • I-Hui Wu,
    • and Gwo-Shing Chen
    High-glucose environment enhanced oxidative stress and increased interleukin-8 secretion from keratinocytes: New insights on impaired diabetic wound healing Diabetes published ahead of print February 19, 2013, doi:10.2337/db12-1714
  5. Banting Lecture 2004:
    • Michael Brownlee
    The Pathobiology of Diabetic Complications: A Unifying Mechanism Diabetes June 2005 54:1615-1625; doi:10.2337/diabetes.54.6.1615
  6. Section II: Type 1-Related Forms of Diabetes:
    • Gunnar Stenström,
    • Anders Gottsäter,
    • Ekaterine Bakhtadze,
    • Bo Berger,
    • and Göran Sundkvist
    Latent Autoimmune Diabetes in Adults: Definition, Prevalence, β-Cell Function, and Treatment Diabetes December 2005 54:S68-S72; doi:10.2337/diabetes.54.suppl_2.S68
  7. Original Research:
    • Alexandra E Butler,
    • Martha Campbell-Thompson,
    • Tatyana Gurlo,
    • David W Dawson,
    • Mark Atkinson,
    • and Peter C Butler
    Marked Expansion of Exocrine and Endocrine Pancreas with Incretin Therapy in Humans with increased Exocrine Pancreas Dysplasia and the potential for Glucagon-producing Neuroendocrine Tumors Diabetes published ahead of print March 22, 2013, doi:10.2337/db12-1686
  8. Perspectives in Diabetes:
    • John W Baynes
    Role of Oxidative Stress in Development of Complications in Diabetes Diabetes April 1991 40:405-412; doi:10.2337/diab.40.4.405
  9. Section I: Insulin Resistance-Beta-Cell Connection in Type 2 Diabetes:
    • Gordon C. Weir and
    • Susan Bonner-Weir
    Five Stages of Evolving Beta-Cell Dysfunction During Progression to Diabetes Diabetes December 2004 53:S16-S21; doi:10.2337/diabetes.53.suppl_3.S16
  10. Perspectives in Diabetes:
    • Edwin A.M. Gale
    The Rise of Childhood Type 1 Diabetes in the 20th Century Diabetes December 2002 51:3353-3361; doi:10.2337/diabetes.51.12.3353
  11. Section 6: Pusatile and Phasic Insulin Release in Normal and Diabetic Men:
    • Errol B. Marliss and
    • Mladen Vranic
    Intense Exercise Has Unique Effects on Both Insulin Release and Its Roles in Glucoregulation: Implications for Diabetes Diabetes February 2002 51:S271-S283; doi:10.2337/diabetes.51.2007.S271
  12. Banting Lecture:
    • Ralph A. DeFronzo
    From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus Diabetes April 2009 58:773-795; doi:10.2337/db09-9028
  13. Section IV: Polygenic Disease and Environment:
    • Mikael Knip,
    • Riitta Veijola,
    • Suvi M. Virtanen,
    • Heikki Hyöty,
    • Outi Vaarala,
    • and Hans K. Åkerblom
    Environmental Triggers and Determinants of Type 1 Diabetes Diabetes December 2005 54:S125-S136; doi:10.2337/diabetes.54.suppl_2.S125
  14. Metabolism and Signal Transduction:
    • Emma M. Bingham,
    • David Hopkins,
    • Diarmuid Smith,
    • Andrew Pernet,
    • William Hallett,
    • Laurence Reed,
    • Paul K. Marsden,
    • and Stephanie A. Amiel
    The Role of Insulin in Human Brain Glucose Metabolism: An 18Fluoro-Deoxyglucose Positron Emission Tomography Study Diabetes December 2002 51:3384-3390; doi:10.2337/diabetes.51.12.3384
  15. Section III: Mitochondria, Beta-Cell Function, and Type 2 Diabetes:
    • Sophie Rousset,
    • Marie-Clotilde Alves-Guerra,
    • Julien Mozo,
    • Bruno Miroux,
    • Anne-Marie Cassard-Doulcier,
    • Frédéric Bouillaud,
    • and Daniel Ricquier
    The Biology of Mitochondrial Uncoupling Proteins Diabetes February 2004 53:S130-S135; doi:10.2337/diabetes.53.2007.S130
  16. Original Articles:
    • Teresita Yap Nelson,
    • James M Oberwetter,
    • James G Chafouleas,
    • and A E Boyd III
    Calmodulin-Binding Proteins in a Cloned Rat Insulinoma Cell Line Diabetes December 1983 32:1126-1133; doi:10.2337/diab.32.12.1126
  17. Perspectives in Diabetes:
    • Fredrik Karpe,
    • Julian R. Dickmann,
    • and Keith N. Frayn
    Fatty Acids, Obesity, and Insulin Resistance: Time for a Reevaluation Diabetes October 2011 60:2441-2449; doi:10.2337/db11-0425
  18. Section III: Inflammation and β-Cell Death:
    • Marc Y. Donath,
    • Jan A. Ehses,
    • Kathrin Maedler,
    • Desiree M. Schumann,
    • Helga Ellingsgaard,
    • Elisabeth Eppler,
    • and Manfred Reinecke
    Mechanisms of β-Cell Death in Type 2 Diabetes Diabetes December 2005 54:S108-S113; doi:10.2337/diabetes.54.suppl_2.S108
  19. Section I: Aspects of Pathophysiology:
    • Peter Achenbach,
    • Ezio Bonifacio,
    • Kerstin Koczwara,
    • and Anette-G. Ziegler
    Natural History of Type 1 Diabetes Diabetes December 2005 54:S25-S31; doi:10.2337/diabetes.54.suppl_2.S25
  20. Commentary:
    • Erik Näslund and
    • Per M. Hellström
    Elucidating the Mechanisms Behind the Restoration of Euglycemia After Gastric Bypass Surgery Diabetes April 2013 62:1012-1013; doi:10.2337/db12-1690
  21. Commentary:
    • Naoyuki Sato and
    • Ryuichi Morishita
    Plasma Aβ: A Possible Missing Link Between Alzheimer Disease and Diabetes Diabetes April 2013 62:1005-1006; doi:10.2337/db12-1549
  22. Perspectives in Diabetes:
    • Christophe M. Filippi and
    • Matthias G. von Herrath
    Viral Trigger for Type 1 Diabetes: Pros and Cons Diabetes November 2008 57:2863-2871; doi:10.2337/db07-1023
  23. Perspectives in Diabetes:
    • Charlotte Ling and
    • Leif Groop
    Epigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes Diabetes December 2009 58:2718-2725; doi:10.2337/db09-1003
  24. Section V: The Incretin Pathway:
    • Maria Sörhede Winzell and
    • Bo Ahrén
    The High-Fat Diet–Fed Mouse: A Model for Studying Mechanisms and Treatment of Impaired Glucose Tolerance and Type 2 Diabetes Diabetes December 2004 53:S215-S219; doi:10.2337/diabetes.53.suppl_3.S215
  25. Commentary:
    • Jill P. Crandall and
    • Nir Barzilai
    Exploring the Promise of Resveratrol: Where Do We Go From Here? Diabetes April 2013 62:1022-1023; doi:10.2337/db12-1788
  26. Pathophysiology:
    • Barbora Vozarova,
    • Christian Weyer,
    • Robert S. Lindsay,
    • Richard E. Pratley,
    • Clifton Bogardus,
    • and P. Antonio Tataranni
    High White Blood Cell Count Is Associated With a Worsening of Insulin Sensitivity and Predicts the Development of Type 2 Diabetes Diabetes February 2002 51:455-461; doi:10.2337/diabetes.51.2.455
  27. Perspectives in Diabetes:
    • Marc T. Hamilton,
    • Deborah G. Hamilton,
    • and Theodore W. Zderic
    Role of Low Energy Expenditure and Sitting in Obesity, Metabolic Syndrome, Type 2 Diabetes, and Cardiovascular Disease Diabetes November 2007 56:2655-2667; published ahead of print September 7, 2007, doi:10.2337/db07-0882
  28. Section III: Inflammation and β-Cell Death:
    • Miriam Cnop,
    • Nils Welsh,
    • Jean-Christophe Jonas,
    • Anne Jörns,
    • Sigurd Lenzen,
    • and Decio L. Eizirik
    Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities Diabetes December 2005 54:S97-S107; doi:10.2337/diabetes.54.suppl_2.S97
  29. Islet Studies:
    • Alexandra E. Butler,
    • Juliette Janson,
    • Susan Bonner-Weir,
    • Robert Ritzel,
    • Robert A. Rizza,
    • and Peter C. Butler
    β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes Diabetes January 2003 52:102-110; doi:10.2337/diabetes.52.1.102
  30. In This Issue: In This Issue of Diabetes Diabetes April 2013 62:1003-1004; doi:10.2337/db13-ti04
    Free Article
  31. Section 3: Beta-Cell Stimulus-Secretion Coupling: K+ ATP Channels and CA2+:
    • Peter Proks,
    • Frank Reimann,
    • Nick Green,
    • Fiona Gribble,
    • and Frances Ashcroft
    Sulfonylurea Stimulation of Insulin Secretion Diabetes December 2002 51:S368-S376; doi:10.2337/diabetes.51.2007.S368
  32. Obesity Studies:
    • Patrice D. Cani,
    • Jacques Amar,
    • Miguel Angel Iglesias,
    • Marjorie Poggi,
    • Claude Knauf,
    • Delphine Bastelica,
    • Audrey M. Neyrinck,
    • Francesca Fava,
    • Kieran M. Tuohy,
    • Chantal Chabo,
    • Aurélie Waget,
    • Evelyne Delmée,
    • Béatrice Cousin,
    • Thierry Sulpice,
    • Bernard Chamontin,
    • Jean Ferrières,
    • Jean-François Tanti,
    • Glenn R. Gibson,
    • Louis Casteilla,
    • Nathalie M. Delzenne,
    • Marie Christine Alessi,
    • and Rémy Burcelin
    Metabolic Endotoxemia Initiates Obesity and Insulin Resistance Diabetes July 2007 56:1761-1772; published ahead of print April 24, 2007, doi:10.2337/db06-1491
  33. Lilly Lecture 2005:
    • Philipp E. Scherer
    Adipose Tissue: From Lipid Storage Compartment to Endocrine Organ Diabetes June 2006 55:1537-1545; doi:10.2337/db06-0263
  34. Perspectives in Diabetes:
    • Frans C. Schuit,
    • Peter Huypens,
    • Harry Heimberg,
    • and Daniel G. Pipeleers
    Glucose Sensing in Pancreatic β-Cells: A Model for the Study of Other Glucose-Regulated Cells in Gut, Pancreas, and Hypothalamus Diabetes January 2001 50:1-11; doi:10.2337/diabetes.50.1.1
  35. Commentaries:
    • Deborah M. Muoio and
    • Christopher B. Newgard
    Fatty Acid Oxidation and Insulin Action: When Less Is More Diabetes June 2008 57:1455-1456; doi:10.2337/db08-0281
  36. Section III: Mitochondria, Beta-Cell Function, and Type 2 Diabetes:
    • J. Antonie Maassen,
    • Leen. M. ‘t Hart,
    • Einar van Essen,
    • Rob J. Heine,
    • Giel Nijpels,
    • Roshan S. Jahangir Tafrechi,
    • Anton K. Raap,
    • George M.C. Janssen,
    • and Herman H.P.J. Lemkes
    Mitochondrial Diabetes: Molecular Mechanisms and Clinical Presentation Diabetes February 2004 53:S103-S109; doi:10.2337/diabetes.53.2007.S103
  37. Perspectives in Diabetes:
    • Guenther Boden
    Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM Diabetes January 1997 46:3-10; doi:10.2337/diab.46.1.3
  38. Metabolism:
    • Patrice D. Cani,
    • Rodrigo Bibiloni,
    • Claude Knauf,
    • Aurélie Waget,
    • Audrey M. Neyrinck,
    • Nathalie M. Delzenne,
    • and Rémy Burcelin
    Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice Diabetes June 2008 57:1470-1481; published ahead of print February 27, 2008, doi:10.2337/db07-1403
  39. Section I: Aspects of Pathophysiology:
    • Tiinamaija Tuomi
    Type 1 and Type 2 Diabetes: What Do They Have in Common? Diabetes December 2005 54:S40-S45; doi:10.2337/diabetes.54.suppl_2.S40
  40. Commentary:
    • Steven E. Kahn
    Incretin Therapy and Islet Pathology – A Time for Caution Diabetes published ahead of print April 17, 2013, doi:10.2337/db13-0520
  41. Section III: The Gastrointestinal Connection:
    • Gareth E. Lim and
    • Patricia L. Brubaker
    Glucagon-Like Peptide 1 Secretion by the L-Cell: The View From Within Diabetes December 2006 55:S70-S77; doi:10.2337/db06-S020
  42. Section II: Type 1-Related Forms of Diabetes:
    • Catherine Pihoker,
    • Lisa K. Gilliam,
    • Christiane S. Hampe,
    • and Åke Lernmark
    Autoantibodies in Diabetes Diabetes December 2005 54:S52-S61; doi:10.2337/diabetes.54.suppl_2.S52
  43. Commentary:
    • Henry A. Erlich,
    • Ana M. Valdes,
    • and Janelle A. Noble
    Prediction of Type 1 Diabetes Diabetes April 2013 62:1020-1021; doi:10.2337/db12-1593
  44. Complications:
    • Christer S. Andreassen,
    • Johannes Jakobsen,
    • and Henning Andersen
    Muscle Weakness: A Progressive Late Complication in Diabetic Distal Symmetric Polyneuropathy Diabetes March 2006 55:806-812; doi:10.2337/diabetes.55.03.06.db05-1237
  45. Complications:
    • Charles M. Alexander,
    • Pamela B. Landsman,
    • Steven M. Teutsch,
    • and Steven M. Haffner
    NCEP-Defined Metabolic Syndrome, Diabetes, and Prevalence of Coronary Heart Disease Among NHANES III Participants Age 50 Years and Older Diabetes May 2003 52:1210-1214; doi:10.2337/diabetes.52.5.1210
  46. Perspectives in Diabetes:
    • R. Paul Robertson,
    • Jamie Harmon,
    • Phuong Oanh Tran,
    • Yoshito Tanaka,
    • and Hiroki Takahashi
    Glucose Toxicity in β-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection Diabetes March 2003 52:581-587; doi:10.2337/diabetes.52.3.581
  47. Banting Lecture:
    • Robert A. Rizza
    Pathogenesis of Fasting and Postprandial Hyperglycemia in Type 2 Diabetes: Implications for Therapy Diabetes November 2010 59:2697-2707; published ahead of print August 12, 2010, doi:10.2337/db10-1032
  48. Perspectives in Diabetes:
    • Jiwen (Jim) Liu,
    • TaeWeon Lee,
    • and Ralph A. DeFronzo
    Why Do SGLT2 Inhibitors Inhibit Only 30–50% of Renal Glucose Reabsorption in Humans? Diabetes September 2012 61:2199-2204; doi:10.2337/db12-0052
  49. Posters: Clinical Diabetes/Therapeutics Diabetes June 2012 61:A212-A344; doi:10.2337/db12-836-1328
  50. Pharmacology and Therapeutics:
    • Belinda Gier,
    • Aleksey V. Matveyenko,
    • David Kirakossian,
    • David Dawson,
    • Sarah M. Dry,
    • and Peter C. Butler
    Chronic GLP-1 Receptor Activation by Exendin-4 Induces Expansion of Pancreatic Duct Glands in Rats and Accelerates Formation of Dysplastic Lesions and Chronic Pancreatitis in the KrasG12D Mouse Model Diabetes May 2012 61:1250-1262; published ahead of print January 20, 2012, doi:10.2337/db11-1109

Last updated 05/04/2013 21:29:57

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