Genetics-Type 2 Diabetes

Genetics-Type 2 Diabetes

Open Access
The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion
Gregor Sachse, Elizabeth Haythorne, Thomas Hill, Peter Proks, Russell Joynson, Raul Terrón-Expósito, Liz Bentley, Stephen J. Tucker, Roger D. Cox, Frances M. Ashcroft

Diabetes May 2021, 70 (5) 1145-1156; DOI: 10.2337/db20-0691
Open Access
Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress
Hossam Montaser, Kashyap A. Patel, Diego Balboa, Hazem Ibrahim, Väinö Lithovius, Anna Näätänen, Vikash Chandra, Korcan Demir, Sezer Acar, Tawfeg Ben-Omran, Kevin Colclough, Jonathan M. Locke, Matthew Wakeling, Maria Lindahl, Andrew T. Hattersley, Jonna Saarimäki-Vire, Timo Otonkoski

Diabetes Apr 2021, 70 (4) 1006-1018; DOI: 10.2337/db20-1174
Open Access
The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium
Shylaja Srinivasan, Ling Chen, Jennifer Todd, Jasmin Divers, Samuel Gidding, Steven Chernausek, Rose A. Gubitosi-Klug, Megan M. Kelsey, Rachana Shah, Mary Helen Black, Lynne E. Wagenknecht, Alisa Manning, Jason Flannick, Giuseppina Imperatore, Josep M. Mercader, Dana Dabelea, Jose C. Florez

Diabetes Apr 2021, 70 (4) 996-1005; DOI: 10.2337/db20-0443
Open Access
Polycystic Ovary Syndrome and Risk of Type 2 Diabetes, Coronary Heart Disease, and Stroke
Tiantian Zhu, Jinrui Cui, Mark O. Goodarzi

Diabetes Feb 2021, 70 (2) 627-637; DOI: 10.2337/db20-0800
Open Access
A Polygenic Score for Type 2 Diabetes Risk Is Associated With Both the Acute and Sustained Response to Sulfonylureas
Josephine H. Li, Lukasz Szczerbinski, Adem Y. Dawed, Varinderpal Kaur, Jennifer N. Todd, Ewan R. Pearson, Jose C. Florez

Diabetes Jan 2021, 70 (1) 293-300; DOI: 10.2337/db20-0530
Open Access
In Vivo Reporter Assays Uncover Changes in Enhancer Activity Caused by Type 2 Diabetes–Associated Single Nucleotide Polymorphisms
Ana Eufrásio, Chiara Perrod, Fábio J. Ferreira, Marta Duque, Mafalda Galhardo, José Bessa

Diabetes Dec 2020, 69 (12) 2794-2805; DOI: 10.2337/db19-1049
Open Access
Active Cigarette Smoking Is Associated With an Exacerbation of Genetic Susceptibility to Diabetes
Wan-Yu Lin, Yu-Li Liu, Albert C. Yang, Shih-Jen Tsai, Po-Hsiu Kuo

Diabetes Dec 2020, 69 (12) 2819-2829; DOI: 10.2337/db20-0156
Open Access
Epigenetic Changes in Islets of Langerhans Preceding the Onset of Diabetes
Meriem Ouni, Sophie Saussenthaler, Fabian Eichelmann, Markus Jähnert, Mandy Stadion, Clemens Wittenbecher, Tina Rönn, Lisa Zellner, Pascal Gottmann, Charlotte Ling, Matthias B. Schulze, Annette Schürmann

Diabetes Nov 2020, 69 (11) 2503-2517; DOI: 10.2337/db20-0204
Open Access
Large-Scale Analyses Provide No Evidence for Gene-Gene Interactions Influencing Type 2 Diabetes Risk
Abhishek Nag, Mark I. McCarthy, Anubha Mahajan

Diabetes Nov 2020, 69 (11) 2518-2522; DOI: 10.2337/db20-0224
Open Access
LDL Cholesterol and Dysglycemia: an Intriguing Physiological Relationship
Jordi Merino, Jerome I. Rotter

Diabetes Oct 2020, 69 (10) 2058-2060; DOI: 10.2337/dbi20-0031

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