Studies on the Site and Mechanism of Action of Phenformin: II. Phenformin Inhibition of Glucose Transport by Rat Intestine

Fred A Kruger; Ruth A Altschuld; Samuel L Hollobaugh; Barbara Jewett

doi:10.2337/diab.19.1.50

Original Contribution

Studies on the Site and Mechanism of Action of Phenformin: II. Phenformin Inhibition of Glucose Transport by Rat Intestine

Fred A Kruger, M.D.,
Ruth A Altschuld, Ph.D.,
Samuel L Hollobaugh, M.D. and
Barbara Jewett, B.S.

Division of Endocrinology and Metabolism, Department of Medicine, Ohio State University Hospitals Columbus, Ohio

Requests for reprints may be addressed to Dr. Kruger, Division of Endocrinology and Metabolism, Ohio State University Hospital, 410 West Tenth Avenue, Columbus, Ohio 43210.

Diabetes 1970 Jan; 19(1): 50-52. https://doi.org/10.2337/diab.19.1.50

Abstract

The effect of oral phenformin on the active transport of glucose by everted sacs of rat intestine was investigated. Pretreatment of the animals with a single dose of the drug resulted in an inhibition of active transport. A log-dose relationship was found in the range studied (5 to 150 mg./kg.). These findings could explain the observation that phenformin increases the tolerance to orally administered glucose but has no effect on intravenous glucose tolerance in humans.