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Original Articles

Glucose Tolerance and Insulin Release, A Mathematical Approach: II. Approximation of the Peripheral Insulin Resistance After Oral Glucose Loading

  1. W J Sluiter, Ph.D.,
  2. D W Erkelens, M.D.,
  3. P Terpstra, M.D.,
  4. W D Reitsma, M.D. and
  5. H Doorenbos, M.D.
  1. Division of Clinical Endocrinology, Department of Internal Medicine, University of Groningen The Netherlands.
Diabetes 1976 Apr; 25(4): 245-249. https://doi.org/10.2337/diab.25.4.245
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Abstract

A parameter of peripheral insulin activity (A = 10(4)/IpGp) can be obtained after oral glucose loading by simple calcuation using insulin and glucose levels at the glucose peak. In combination with a glucose-independent parameter of beta-cell function (CIR = 100· I/G(G-70) a parameter of glucose tolerance (GT = A · CIR) is defined. The parameters allow one to separate the contributions of beta-cell function and peripheral insulin resistance to the glucose tolerance observed after glucose loading. Examples, based on the literature and our own work, illustrate the increase of A and GT by cortisone acetate premedication as well as long-term oral contraceptive medication.

  • Accepted December 10, 1975.
  • Copyright © 1976 by the American Diabetes Association

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April 1976, 25(4)
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Glucose Tolerance and Insulin Release, A Mathematical Approach: II. Approximation of the Peripheral Insulin Resistance After Oral Glucose Loading
W J Sluiter, D W Erkelens, P Terpstra, W D Reitsma, H Doorenbos
Diabetes Apr 1976, 25 (4) 245-249; DOI: 10.2337/diab.25.4.245

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Glucose Tolerance and Insulin Release, A Mathematical Approach: II. Approximation of the Peripheral Insulin Resistance After Oral Glucose Loading
W J Sluiter, D W Erkelens, P Terpstra, W D Reitsma, H Doorenbos
Diabetes Apr 1976, 25 (4) 245-249; DOI: 10.2337/diab.25.4.245
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