Glucose Tolerance and Insulin Release, A Mathematical Approach: II. Approximation of the Peripheral Insulin Resistance After Oral Glucose Loading
Abstract
A parameter of peripheral insulin activity (A = 10(4)/IpGp) can be obtained after oral glucose loading by simple calcuation using insulin and glucose levels at the glucose peak. In combination with a glucose-independent parameter of beta-cell function (CIR = 100· I/G(G-70) a parameter of glucose tolerance (GT = A · CIR) is defined. The parameters allow one to separate the contributions of beta-cell function and peripheral insulin resistance to the glucose tolerance observed after glucose loading. Examples, based on the literature and our own work, illustrate the increase of A and GT by cortisone acetate premedication as well as long-term oral contraceptive medication.
- Accepted December 10, 1975.
- Copyright © 1976 by the American Diabetes Association
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In this Issue
April 1976, 25(4)
Glucose Tolerance and Insulin Release, A Mathematical Approach: II. Approximation of the Peripheral Insulin Resistance After Oral Glucose Loading
