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Articles

Genetic Selection for Diabetogenic Traits in Yucatan Miniature Swine

  1. R W Phillips,
  2. L M Panepinto and
  3. D H Will
  1. Department of Physiology and Biophysics, College of Veterinary Medicine and Biomedicai Sciences, Colorado State University Fort Collins, Colorado 80523
Diabetes 1979 Dec; 28(12): 1102-1107. https://doi.org/10.2337/diab.28.12.1102
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Abstract

Yucatan miniature pigs have been selectively bred for reduced and increased glucose clearance during an intravenous glucose tolerance test. Pigs with low glucose clearance rates (low K) have been selected through the F-5 generation. They have a significantly reduced rate of glucose clearance and a blunted peripheral IRI increase in response to the challenge. Through the F-5 generation, heritability of glucose tolerance is estimated at 0.26. Sporadic fasting blood glucoses in excess of 100 mg/dl are seen in later generations of this group. High glucose clearance pigs (high K) have been selected through the F-4 generation. They have significantly increased rates of glucose clearance and a greater increase in peripheral IRI than the low K animals. The estimated heritability for high K through the F-4 generation is 0.31. No evidence of fasting hypo- or hyperglycemia has been seen in the high K animals.

  • Revision received August 17, 1979.
  • Accepted August 17, 1979.
  • Copyright © 1979 by the American Diabetes Association

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December 1979, 28(12)
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Genetic Selection for Diabetogenic Traits in Yucatan Miniature Swine
R W Phillips, L M Panepinto, D H Will
Diabetes Dec 1979, 28 (12) 1102-1107; DOI: 10.2337/diab.28.12.1102

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Genetic Selection for Diabetogenic Traits in Yucatan Miniature Swine
R W Phillips, L M Panepinto, D H Will
Diabetes Dec 1979, 28 (12) 1102-1107; DOI: 10.2337/diab.28.12.1102
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© 2019 by the American Diabetes Association. Diabetes Print ISSN: 0012-1797, Online ISSN: 1939-327X.