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Original Contributions

One Month of Sustained Release of Insulin from a Polymer Implant

  1. Halimena M Creque,
  2. Robert Langer and
  3. Judah Folkman
  1. Department of Surgery, Children's Hospital Medical Center and Harvard Medical School Boston, Massachusetts Department of Nutrition and Food Science, Massachusetts Institute of Technology Cambridge, Massachusetts 02139
  1. Address reprint requests to Judah Folkman, M.D., Children's Hospital Medical Center, 300 Longwood Avenue, Boston, Massachusetts 02115.
Diabetes 1980 Jan; 29(1): 37-40. https://doi.org/10.2337/diab.29.1.37
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Abstract

Rats made diabetic with streptozotocin received a single subcutaneous implant of an insulin polymer pellet that released insulin continuously at approximately 2 U/day. Continuous normoglycemia was achieved for up to 1 mo. Mean glucose level for treated animals was 113 mg/dl as compared with 398 mg/dl for untreated diabetic controls. Diurnal blood glucose values for treated animals ranged from 71 to 116 mg/dl. Polyuria and glycosuria were corrected by the presence of the insulin + polymer. Treated animals gained weight normally and reached a mean weight of 350 g, whereas untreated control animals lost weight, to a mean of 150 g. When insulin + polymer preparations were periodically implanted and removed at 7-day intervals, normoglycemia was only associated with the presence of implants.

  • Received January 8, 1979.
  • Copyright © 1980 by the American Diabetes Association

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January 1980, 29(1)
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One Month of Sustained Release of Insulin from a Polymer Implant
Halimena M Creque, Robert Langer, Judah Folkman
Diabetes Jan 1980, 29 (1) 37-40; DOI: 10.2337/diab.29.1.37

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One Month of Sustained Release of Insulin from a Polymer Implant
Halimena M Creque, Robert Langer, Judah Folkman
Diabetes Jan 1980, 29 (1) 37-40; DOI: 10.2337/diab.29.1.37
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© 2021 by the American Diabetes Association. Diabetes Print ISSN: 0012-1797, Online ISSN: 1939-327X.