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Original contribution

Production of 6-Oxo-Prostaglandin F1α by Rat Aorta: Influence of Diabetes, Insulin Treatment, and Caloric Deprivation

  1. Susan P Rogers and
  2. Richard G Larkins
  1. University of Melbourne, Department of Medicine, Repatriation General Hospital Heidelberg, Victoria, 3081. Australia
  1. Address reprint requests to Susan Rogers at the above address.
Diabetes 1981 Nov; 30(11): 935-939. https://doi.org/10.2337/diab.30.11.935
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Abstract

The production of 6-oxo-prostaglandin F1α (6-oxo-PGF1α), a stable metabolite of prostacyclin (PGI2), was examined in three separate series of experiments in aortae from rats with diabetes induced by streptozotocin (SZ) and aortae from nondiabetic control rats.

In the first series, it was shown that production of 6-oxo-PGF1α by aortae from rats with diabetes of 4–6-wk duration was significantly decreased compared with nondiabetic rats (0.77 ± 0.07 ng/mg wet weight aorta vs. 1.23 ± 0.11 ng/mg wet weight aorta, P < 0.001). Diabetic rats were treated with two doses of insulin, a lower dose of 8 U/kg/day that only partially corrected their plasma glucose and body weight compared with nondiabetic rats, and a higher dose of 25 U/kg/day that completely corrected their plasma glucose and body weight. Both insulin regimens completely reversed the defect in 6-oxo-PGF1α production.

In the second series, the time course of development of the defect in 6-oxo-PGF1α production was examined. It was found that two weeks after induction of diabetes, the aortic production of 6-oxo-PGF1α did not differ between control and diabetic rats. However, 4 and 7 wk after induction of diabetes, 6-oxo-PGF1α production was significantly reduced, even though the degree of hyperglycemia and hypoinsulinemia was the same as at 2 wk.

In the third series, the effect on aortic 6-oxo-PGF1α production of weight loss caused by restricted dietary intake was compared with the effect of a comparable weight loss caused by experimental diabetes. Again, the diabetic rats had significantly reduced 6-oxo-PGF1α production compared with control rats, but 6-oxo-PGF1α production in nondiabetic rats which had lost weight as a result of limited feeding was the same as nondiabetic control rats fed ad libitum.

It is concluded (1) that insulin treatment, even if insufficient to achieve perfect control of plasma glucose, can restore 6-oxo-PGF1α production to normal, (2) diabetes of greater than 2-wk duration is required to produce the abnormality, and (3) the reduced 6-oxo-PGF1α production is not a nonspecific consequence of weight loss.

  • Received August 29, 1980.
  • Revision received June 29, 1981.
  • Accepted June 29, 1981.
  • Copyright © 1981 by the American Diabetes Association

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November 1981, 30(11)
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Production of 6-Oxo-Prostaglandin F1α by Rat Aorta: Influence of Diabetes, Insulin Treatment, and Caloric Deprivation
Susan P Rogers, Richard G Larkins
Diabetes Nov 1981, 30 (11) 935-939; DOI: 10.2337/diab.30.11.935

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Production of 6-Oxo-Prostaglandin F1α by Rat Aorta: Influence of Diabetes, Insulin Treatment, and Caloric Deprivation
Susan P Rogers, Richard G Larkins
Diabetes Nov 1981, 30 (11) 935-939; DOI: 10.2337/diab.30.11.935
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  • Nutrition and Somatomedin: XVII. Circulating Somatomedin C During Treatment of Diabetic Ketoacidosis
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  • Subunit Structure, Autophosphorylation, and Tyrosine-Specific Protein Kinase Activity of Hepatic Insulin Receptors in Fetal, Neonatal, and Adult Rats
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© 2019 by the American Diabetes Association. Diabetes Print ISSN: 0012-1797, Online ISSN: 1939-327X.