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Original contribution

Brief, Irregular Oscillations of Basal Plasma Insulin and Glucose Concentrations in Diabetic Man

  1. D A Lang,
  2. D R Matthews,
  3. M Burnett and
  4. R C Turner
  1. Diabetic Research Laboratories, Nuffield Department of Clinical Medicine, Radcliffe Infirmary Oxford OX2 6HE, United Kingdom
  1. Address reprint requests to Dr. R. C. Turner at the above address.
Diabetes 1981 May; 30(5): 435-439. https://doi.org/10.2337/diab.30.5.435
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Abstract

The basal plasma insulin and glucose concentrations of 12 diet-treated maturity-onset diabetics were measured at minute intervals for 2 h. Brief, irregular oscillations (mean period 8.8 min) in plasma insulin were superimposed on longer term fluctuations (> 30 min). Time series analysis demonstrated a synchronous plasma glucose oscillation (mean amplitude 0.03 mmol/L) associated with short insulin cycles. The glucose changes seen in diabetic subjects were similar to the short plasma insulin cycles (< 10 min) observed in normal subjects. In contrast, the longer plasma insulin cycles (> 10 min) of normal subjects were associated with a plasma glucose oscillation that rose before the end of the cycle. The demonstration of insulin oscillations independent of preceding plasma glucose changes in both normal and diabetic subjects suggests a pancreatic oscillating mechanism or “pacemaker.” The associated glucose changes may reflect the entrainment, by the insulin cycles, of glucose production or utilization.

  • Received May 13, 1980.
  • Revision received October 27, 1980.
  • Accepted October 27, 1980.
  • Copyright © 1981 by the American Diabetes Association
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May 1981, 30(5)
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Brief, Irregular Oscillations of Basal Plasma Insulin and Glucose Concentrations in Diabetic Man
D A Lang, D R Matthews, M Burnett, R C Turner
Diabetes May 1981, 30 (5) 435-439; DOI: 10.2337/diab.30.5.435

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Brief, Irregular Oscillations of Basal Plasma Insulin and Glucose Concentrations in Diabetic Man
D A Lang, D R Matthews, M Burnett, R C Turner
Diabetes May 1981, 30 (5) 435-439; DOI: 10.2337/diab.30.5.435
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