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Rapid Publications

Cardiac Arrhythmias During Epinephrine-Propranolol Infusions for Measurement of In Vivo Insulin Resistance

  1. Richard M Lampman,
  2. John T Santinga,
  3. David R Bassett and
  4. Peter J Savage
  1. Department of Internal Medicine, Divisions of Cardiology, Hypertension, and Endocrinology and Metabolism, The University of Michigan Ann Arbor, Michigan
  1. Address reprint requests to Richard M. Lampman, Ph.D., Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, 1405 East Ann Street, Ann Arbor, Michigan 48109.
Diabetes 1981 Jul; 30(7): 618-620. https://doi.org/10.2337/diab.30.7.618
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Abstract

Sixty-eight determinations of in vivo insulin resistance were conducted in 35 males (aged 29-63 yr) by measurement of steady-state plasma glucose levels during a combined intravenous infusion of propranolol, epinephrine, glucose, and insulin. Subjects were mildly diabetic and/or hyperlipidemic. All were asymptomatic, denied taking medication, and had no history of cardiac disease. All had normal resting electrocardiograms. During the infusion, mean increases in systolic and diastolic blood pressure were 27 ± 12.2 (X¯ ± SD) and 14 ± 5.7 mm Hg, respectively;, mean reduction in heart rate was 19 ± 6.1 beats/min. Six out of the 35 subjects developed cardiac arrhythmias during the infusion test. Maximal exercise treadmill tests failed to predict all subjects who subsequently developed arrhythmias during the infusion test. These results suggest that this infusion test should be performed under continuous cardiac monitoring and promptly terminated if major arrhythmias develop.

  • Received April 10, 1981.
  • Copyright © 1981 by the American Diabetes Association
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July 1981, 30(7)
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Cardiac Arrhythmias During Epinephrine-Propranolol Infusions for Measurement of In Vivo Insulin Resistance
Richard M Lampman, John T Santinga, David R Bassett, Peter J Savage
Diabetes Jul 1981, 30 (7) 618-620; DOI: 10.2337/diab.30.7.618

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Cardiac Arrhythmias During Epinephrine-Propranolol Infusions for Measurement of In Vivo Insulin Resistance
Richard M Lampman, John T Santinga, David R Bassett, Peter J Savage
Diabetes Jul 1981, 30 (7) 618-620; DOI: 10.2337/diab.30.7.618
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