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Original contribution

Glycosylated Fetal Hemoglobin: Correlation with Hyperglycemia and Birth Weight in Infants of Diabetic Mothers

  1. Felix Feldman,
  2. Harry Rubin,
  3. Ismat Nawabi,
  4. Ann Marie Abbondante,
  5. Norman A Posner and
  6. Nicholas I Stefanyshyn
  1. Departments of Pediatrics, Internal Medicine, and Obstetrics and Gynecology, Maimonides Medical Center Brooklyn, New York
  1. Address reprint requests to Felix Feldman, M.D., Department of Pediatrics, Maimonides Medical Center, 4802 10th Avenue, Brooklyn, New York 11219.
Diabetes 1984 Jan; 33(1): 81-85. https://doi.org/10.2337/diab.33.1.81
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Abstract

Glycosylated fetal hemoglobin levels were measured in umbilical cord blood of normal infants and infants of diabetic mothers. The glycosylated fraction proved to be a stable compound; its level remained unchanged over a 19-day period. Exposure of fetal and adult hemoglobins to the same concentrations of glucose in vitro resulted in similar levels of glycosylated hemoglobins, suggesting that both types of hemoglobin are about equally reactive with glucose. Levels of glycosylated hemoglobin were significantly increased above normal in umbilical cord blood of infants of both Class A and Class B diabetic mothers. A significant relationship was found between macrosomia, reflected in birth weight ratios, and glycosylated hemoglobin from fetal erythrocytes in infants of diabetic mothers. While these data are consistent with the conclusion that glycosylated fetal hemoglobin levels are a function of fetal blood glucose concentrations in utero during the 2 mo before delivery, it is not known whether the glycosylated hemoglobin contributes to the abnormalities other than macrosomia found in infants of diabetic mothers.

  • Received January 31, 1983.
  • Revision received July 13, 1983.
  • Accepted July 13, 1983.
  • Copyright © 1984 by the American Diabetes Association

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January 1984, 33(1)
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Glycosylated Fetal Hemoglobin: Correlation with Hyperglycemia and Birth Weight in Infants of Diabetic Mothers
Felix Feldman, Harry Rubin, Ismat Nawabi, Ann Marie Abbondante, Norman A Posner, Nicholas I Stefanyshyn
Diabetes Jan 1984, 33 (1) 81-85; DOI: 10.2337/diab.33.1.81

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Glycosylated Fetal Hemoglobin: Correlation with Hyperglycemia and Birth Weight in Infants of Diabetic Mothers
Felix Feldman, Harry Rubin, Ismat Nawabi, Ann Marie Abbondante, Norman A Posner, Nicholas I Stefanyshyn
Diabetes Jan 1984, 33 (1) 81-85; DOI: 10.2337/diab.33.1.81
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