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Original Contribution

Tissue-specific Antibodies Against the Fibroblast Insulin Receptor in a Patient with Lupus Nephritis and Hypoglycemia

  1. Roberto De Pirro,
  2. Patrizia Borboni,
  3. Renato Lauro,
  4. Antonella Festa,
  5. Ivano Testa,
  6. Carlo De Martinis,
  7. Betty A Maddux and
  8. Ira D Goldfine
  1. Endocrinologia e Medicina Costituzionale, II Universitá di Roma “Tor Vergata” Rome, Italy
  2. Clinica Medica, Universitá di Ancona Ancona, Italy
  3. Mt. Zion Hospital and Medical Center San Francisco, California
  1. Address reprint requests to I. D. Goldfine, M.D., Cell Biology Laboratory, Mt. Zion Medical Center, 1600 Divisadero Street, San Francisco, California 94120.
Diabetes 1985 Nov; 34(11): 1088-1091. https://doi.org/10.2337/diab.34.11.1088
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Abstract

We recently reported that the serum from a patient with lupus nephritis, insulin resistance, and hypoglycemia contains multiple populations of antibodies directed at the human insulin receptor. In the present study, we found a subpopulation of antibodies (eluted from a protein A-Sepharose affinity column at pH 4.3) directed at the human fibroblast insulin receptor. When tested against human placental membranes, IM-9 lymphocytes, circulating monocytes and erythrocytes,and isolated adipocytes, the antibody subpopulation did not compete with 125I-insulin for binding to its receptor. In contrast, the antibody subpopulation competed with 125I-insulin for binding to the human fibroblast insulin receptor. This antibody subpopulation stimulated [3H]aaminoisobutyric acid ([3H]AIB) uptake to these cells. Unlike the effect of insulin, however, this regulation of transport was not antagonizedby a mouse monoclonal antibody to the human insulin receptor that inhibits 125Iinsulinbinding. These studies indicate, therefore, that a tissue-specific antibody subpopulation can occur spontaneously in patients with antibodies to the human insulin receptor. Furthermore, they indicate the presence of anti-insulin receptor autoantibodies specifically directed against a tissue that is not primarily involved in glucose metabolism.

  • Received January 29, 1985.
  • Revision received May 28, 1985.
  • Copyright © 1985 by the American Diabetes Association

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November 1985, 34(11)
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Tissue-specific Antibodies Against the Fibroblast Insulin Receptor in a Patient with Lupus Nephritis and Hypoglycemia
Roberto De Pirro, Patrizia Borboni, Renato Lauro, Antonella Festa, Ivano Testa, Carlo De Martinis, Betty A Maddux, Ira D Goldfine
Diabetes Nov 1985, 34 (11) 1088-1091; DOI: 10.2337/diab.34.11.1088

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Tissue-specific Antibodies Against the Fibroblast Insulin Receptor in a Patient with Lupus Nephritis and Hypoglycemia
Roberto De Pirro, Patrizia Borboni, Renato Lauro, Antonella Festa, Ivano Testa, Carlo De Martinis, Betty A Maddux, Ira D Goldfine
Diabetes Nov 1985, 34 (11) 1088-1091; DOI: 10.2337/diab.34.11.1088
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  • Calculated Pattern of Intraportal Insulin Appearance Without Independent Assessment of C-Peptide Kinetics
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