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Original Contribution

Biohybrid Artificial Pancreas Long-Term Insulin Secretion by Devices Seeded with Canine Islets

  1. Yoshimasa Araki,
  2. Barry A Solomon,
  3. Richard M Basile and
  4. William L Chick
  1. Departments of Biochemistry and Medicine ,University of Massachusetts Medical Center Worcester, Massachusetts
  2. Surgery, University of Massachusetts Medical Center Worcester, Massachusetts
  3. Amicon Corporation Lexington, Massachusetts
  1. Address reprint requests to William L. Chick, M.D., Department of Biochemistry, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, Massachusetts 01605.
Diabetes 1985 Sep; 34(9): 850-854. https://doi.org/10.2337/diab.34.9.850
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Abstract

Long-term insulin secretion was investigated in seven biohybrid capillary devices seeded with canine islets. Approximately 50,000 islets could be isolated from a single canine pancreas using collagenase digestion in conjunction with the recently described Velcro technique. Devices were perfused with tissue culture medium 199 containing 300 mg/dl glucose. Insulin secretion fell during the first 1–2 days of culture from approximately 18 to 6 U/day. After 3–4 wk of perfusion, however, there was a gradual rise in insulin output that reached >15 U/day after 7 wk. Insulin output eventually stabilized at 18–20 U/day. Two of these devices were studied for 80 and 86 days, respectively, and continued to secrete these same amounts of insulin. Glucose-induced insulin release was studied after 1 and 4 wk of culture and was well preserved.

  • Received December 12, 1984.
  • Revision received March 14, 1985.
  • Copyright © 1985 by the American Diabetes Association

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September 1985, 34(9)
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Biohybrid Artificial Pancreas Long-Term Insulin Secretion by Devices Seeded with Canine Islets
Yoshimasa Araki, Barry A Solomon, Richard M Basile, William L Chick
Diabetes Sep 1985, 34 (9) 850-854; DOI: 10.2337/diab.34.9.850

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Biohybrid Artificial Pancreas Long-Term Insulin Secretion by Devices Seeded with Canine Islets
Yoshimasa Araki, Barry A Solomon, Richard M Basile, William L Chick
Diabetes Sep 1985, 34 (9) 850-854; DOI: 10.2337/diab.34.9.850
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