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Original Contribution

Streptozocin-induced Diabetes Affects Rat Urinary Bladder Response to Autonomic Agents

  1. Malak G Kolta,
  2. Lane J Wallace and
  3. Michael C Gerald
  1. Division of Pharmacology, College of Pharmacy, Ohio State University 500 W 12th Avenue, Columbus, Ohio 43210
  1. Address reprint requests to L. J. Wallace at the above address.
Diabetes 1985 Sep; 34(9): 917-921. https://doi.org/10.2337/diab.34.9.917
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Abstract

The response of the urinary bladder body and base to autonomic agents was studied instreptozocin (STZ)-diabetic rats. The bladder body region from 6-wk diabetic rats showed no changes in response to acetylcholine, phenylephrine, or isoproterenol. In contrast, the bladder base region showed a 39% increase in contractile response to acetylcholine and a 37% increased response to phenylephrine. In tissues from 47-wk diabetic animals, the bladder body showed a 51% increased contractile response to acetylcholine and a 37% increased relaxation response to isoproterenol. The bladder base showed a 66% increased contraction to acetylcholine. Thus, in the bladder base, enhanced responses to acetylcholine are detected soon after induction of diabetes and continue to increase as the diabetic state progresses. Moreover, in the same bladder region, an increase in responsiveness to alphaadrenergic stimuli occurs. In the bladder body, enhanced responses to cholinergic and to beta-adrenergic stimuli occur, but are only observed in a more chronic diabetic state. The data suggest that an effect associated with autonomic diabetic neuropathy of the urinary bladder is an increased postsynaptic responsiveness to cholinergic stimuli in both regions.

  • Received July 23, 1984.
  • Revision received December 24, 1984.
  • Copyright © 1985 by the American Diabetes Association
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September 1985, 34(9)
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Streptozocin-induced Diabetes Affects Rat Urinary Bladder Response to Autonomic Agents
Malak G Kolta, Lane J Wallace, Michael C Gerald
Diabetes Sep 1985, 34 (9) 917-921; DOI: 10.2337/diab.34.9.917

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Streptozocin-induced Diabetes Affects Rat Urinary Bladder Response to Autonomic Agents
Malak G Kolta, Lane J Wallace, Michael C Gerald
Diabetes Sep 1985, 34 (9) 917-921; DOI: 10.2337/diab.34.9.917
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