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Original Contribution

Virus-induced Diabetes Mellitus: No Evidence for Immune Mechanisms in the Destruction of β-Cells by the D-Variant of Encephalomyocarditis Virus

  1. Ji-Won Yoon,
  2. Patrick R McClintock,
  3. Cindy J Bachurski,
  4. Janice D Longstreth and
  5. Abner Louis Notkins
  1. Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health Bethesda, Maryland
  2. Laboratory of Microbial Immunity, National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland
  1. Address reprint requests to A. L. Notkins, M.D., National Institute of Dental Research, Building 30, Room 121, National Institutes of Health, Bethesda, Maryland 20205
Diabetes 1985 Sep; 34(9): 922-925. https://doi.org/10.2337/diab.34.9.922
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Abstract

A possible contribution of the immune system to the pathogenesis of virus-induced diabetes mellitus was investigated using the D-variant of encephalomyocarditis (EMC-D) virus. Studies on the F1 and backcross progeny of susceptible and resistant strains of mice gave no suggestion of a linkage between susceptibility and the major histocompatibility locus. Immunosuppression by antilymphocyte serum did not prevent the induction of EMC-D-induced diabetes. Athymic nude mice infected with EMC-D virus showed a nearly identical diabetogenic response as comparedwith heterozygous litter mates. Passive transfer of lymphocytes from mice made diabetic with EMC-D virus into normal mice failed to produce diabetes. From these and other studies, we conclude that the development of EMC-Dinduced diabetes is due to the direct destruction of β-cells by the virus and that the contribution of the immune response to the pathogenesis of this disease is, at the most, minor.

  • Received November 13, 1984.
  • Revision received March 1, 1985.
  • Copyright © 1985 by the American Diabetes Association
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September 1985, 34(9)
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Virus-induced Diabetes Mellitus: No Evidence for Immune Mechanisms in the Destruction of β-Cells by the D-Variant of Encephalomyocarditis Virus
Ji-Won Yoon, Patrick R McClintock, Cindy J Bachurski, Janice D Longstreth, Abner Louis Notkins
Diabetes Sep 1985, 34 (9) 922-925; DOI: 10.2337/diab.34.9.922

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Virus-induced Diabetes Mellitus: No Evidence for Immune Mechanisms in the Destruction of β-Cells by the D-Variant of Encephalomyocarditis Virus
Ji-Won Yoon, Patrick R McClintock, Cindy J Bachurski, Janice D Longstreth, Abner Louis Notkins
Diabetes Sep 1985, 34 (9) 922-925; DOI: 10.2337/diab.34.9.922
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