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Original Contributions

Increased Frequency of Apolipoprotein ∈4 Allele in Type II Diabetes With Hypercholesterolemia

  1. Masaaki Eto,
  2. Kiyoshi Watanabe,
  3. Yasunori Iwashima,
  4. Akizuki Morikawa,
  5. Norihide Chonan,
  6. Eiji Oshima,
  7. Masatomo Sekiguchi and
  8. Kaneo Ishii
  1. Second Department of Internal Medicine, Asahikawa Medical College Asahikawa, Japan
  1. Address correspondence and reprint requests to Masaaki Eto, MD, The Second Department of Internal Medicine, Asahikawa Medical College, Nishikagura 4-5, Asahikawa 078, Japan
Diabetes 1987 Nov; 36(11): 1301-1306. https://doi.org/10.2337/diab.36.11.1301
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Abstract

The apolipoprotein E (apoE) phenotype and allele frequencies were examined in type II (non-insulindependent) diabetic patients with normolipidemia (n = 134) and hypercholesterolemia (type IIa hyperlipoproteinemia, n = 35; type lib hyperlipoproteinemia, n = 42). The frequencies of apoE4-present phenotypes (apoE4/3, apoE4/4, and apoE4/2) were highest in the type IIa group (51.4%), followed by the type Mb group (38.1%) and the normolipidemic group (16.4%), respectively, whereas the frequency of the most common phenotype, apoE3/3, was lowest in the type IIa group (48.6%), followed by the type lib group (61.9%) and the normolipidemic group (79.9%), respectively. There were significant differences in the apoE phenotype frequencies between the normolipidemic group and the type IIa and Mb groups. The frequency of the ∈4 allele was significantly higher in the type IIa (28.6%) and Mb (20.2%) groups than in the normolipidemic group (8.9%), whereas the frequency of the ∈3 allele was significantly lower in the type IIa (71.4%) and Mb (78.6%) groups than in the normolipidemic group (89.2%). The frequency of the ∈2 allele tended to be lower in diabetic patients with hypercholesterolemia. In addition, these frequencies were also examined in nondiabetic subjects (n = 59). The frequency of the ∈4 allele tended to be higher in hypercholesterolemic diabetic subjects (24.1%) than in hypercholesterolemicnondiabetic subjects (15.3%). These data suggest that diabetic patients with the ∈4 allele may be more susceptible to hypercholesterolemia than diabetic patients without the ∈4 allele and possibly nondiabetic subjects with the ∈4 allele, although the underlying mechanism is unknown.

  • Received January 2, 1987.
  • Revision received April 24, 1987.
  • Accepted April 24, 1987.
  • Copyright © 1987 by the American Diabetes Association

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November 1987, 36(11)
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Increased Frequency of Apolipoprotein ∈4 Allele in Type II Diabetes With Hypercholesterolemia
Masaaki Eto, Kiyoshi Watanabe, Yasunori Iwashima, Akizuki Morikawa, Norihide Chonan, Eiji Oshima, Masatomo Sekiguchi, Kaneo Ishii
Diabetes Nov 1987, 36 (11) 1301-1306; DOI: 10.2337/diab.36.11.1301

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Increased Frequency of Apolipoprotein ∈4 Allele in Type II Diabetes With Hypercholesterolemia
Masaaki Eto, Kiyoshi Watanabe, Yasunori Iwashima, Akizuki Morikawa, Norihide Chonan, Eiji Oshima, Masatomo Sekiguchi, Kaneo Ishii
Diabetes Nov 1987, 36 (11) 1301-1306; DOI: 10.2337/diab.36.11.1301
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