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Original Articles

Alterations in Free Radical Tissue-Defense Mechanisms in Streptozocin-Induced Diabetes in Rat: Effects of Insulin Treatment

  1. Saleh A Wohaieb and
  2. David V Godin
  1. Department of Pharmacology and Therapeutics, Faculty of Medicine, The University of British Columbia Vancouver, British Columbia, Canada
  1. Address correspondence and reprint requests to Dr. David V. Godin, Dept. of Phamacology and Therapeutics, The University of British Columbia, 2176 Health Sciences Mall, Vancouver, British Columbia V6T 1W5, Canada.
Diabetes 1987 Sep; 36(9): 1014-1018. https://doi.org/10.2337/diab.36.9.1014
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Abstract

We investigated the possible involvement of reactive oxygen radical-related processes in chronic (12-wk) diabetes induced in rats by streptozocin (STZ). Diabetes was associated with significantly increased activities of catalase (CAT), glutathione reductase (GSSG-RD), and CuZn-superoxide dismutase (SOD) in the pancreas and of CAT and GSSG-RD in the heart. On the other hand, the liver of diabetic rats showed a generalized decrease in CAT, glutathione peroxidase (GSH-PX), and SOD as well as in the levels of reduced glutathione (GSH). Diabetic kidney also showed decreases in CAT and SOD, but the activities of GSH-PX were increased. Insulin treatment (9–12 U/kg body wt) that was started after 8 wk of diabetes and continued for 4 wk reversed all of the foregoing alterations in tissue antioxidant status.

Our results suggest the presence of increased oxidative stress in uncontrolled diabetes as manifested by the marked alterations in tissue antioxidant enzyme activities, the magnitude of which increased with the degree of emaciation. The complex patterns of changes observed in the various tissues examined are believed to be the result of compensatory increases in enzyme activities (usually involving enzymes whose activity in control tissues is low) and direct inhibitory effects, possibly resulting from an increased tissue-oxidant activity. Our findings support the view that tissue antioxidant status may be an important factor in the etiology of diabetes and its complications.

  • Received December 11, 1986.
  • Revision received February 19, 1987.
  • Accepted February 19, 1987.
  • Copyright © 1987 by the American Diabetes Association

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September 1987, 36(9)
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Alterations in Free Radical Tissue-Defense Mechanisms in Streptozocin-Induced Diabetes in Rat: Effects of Insulin Treatment
Saleh A Wohaieb, David V Godin
Diabetes Sep 1987, 36 (9) 1014-1018; DOI: 10.2337/diab.36.9.1014

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Alterations in Free Radical Tissue-Defense Mechanisms in Streptozocin-Induced Diabetes in Rat: Effects of Insulin Treatment
Saleh A Wohaieb, David V Godin
Diabetes Sep 1987, 36 (9) 1014-1018; DOI: 10.2337/diab.36.9.1014
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