Evidence of IgG Autoantibodies Against Human Proinsulin in Patients With IDDM Before Insulin Treatment
Abstract
IgG proinsulin autoantibodies (IgG-PAAs) have been found in a fraction of sera from patients with newly diagnosed insulin-dependent diabetes mellitus (IDDM) before onset of insulin treatment. Only sera lacking insulin antibodies have been analyzed, to avoid interference. Competitive inhibition studies provide specificity for human proinsulin but not for insulin. IgG-PAAs largely cross-react with human C-peptide. Precursors of insulin thus are involved in the immune process of IDDM.
- Received September 8, 1987.
- Accepted September 28, 1987.
- Copyright © 1988 by the American Diabetes Association
In this Issue
January 1988, 37(1)
Evidence of IgG Autoantibodies Against Human Proinsulin in Patients With IDDM Before Insulin Treatment
