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Original Articles

Specific Immunity to Streptozocin: Cellular Requirements for Induction of Lymphoproliferation

  1. Christiane Klinkhammer,
  2. Poly Popowa and
  3. Helga Gleichmann
  1. Clinical Department, Diabetes Research Institute, University of Düsseldorf Düsseldorf, Federal Republic of Germany
  1. Address correspondence and reprint requests to Prof. Helga Gleichmann, Diabetes-Forschungsinstitut, Auf'm Hennekamp 65, D-4000 Dusseldorf 1, FRG.
Diabetes 1988 Jan; 37(1): 74-80. https://doi.org/10.2337/diab.37.1.74
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Abstract

The mechanism(s) of the immunological reactions involved in the pathogenesis of hyperglycemia induced by multiple intraperitoneal injections of subdiabetogenic doses of streptozocin (STZ) in mice remains to be elucidated. We found that STZ can act as a hapten in vivo by using the popliteal lymph node (PLN) assay. With this assay a direct toxic effect of STZ on the pancreatic β-cells was dissociated from the effects exerted on the immune system. Subcutaneous injections of STZ induced immune reactivity in the draining PLN as determined by increase in weight, cell number, and [3H]thymidine incorporation. T-lymphocytes were required to induce the PLN response to STZ, because athymic nu/nu mice completely failed to respond to STZ, in contrast to their euthymic +/nu counterparts (P < .001). The STZ-induced PLN response was sex independent and unaffected by prior subcutaneous injections of 3-O-methylglucose known to protect pancreatic β-cells against STZ. STZ-primed mice exhibited an accelerated and enhanced STZ-specific secondary PLN response on challenge with subimmunogenic doses of STZ. In adoptive transfer experiments, STZ-sensitized splenic lymphocytes enriched for T-lymphocytes induced an STZ-specific significant (P < .005) PLN enlargement provided the syngeneic recipients had been pretreated with subimmunogenic doses of STZ. Presumably, such STZ-specific immune reactions enhance a subtoxic effect of STZ on the pancreatic β-cells.

  • Received May 1, 1987.
  • Revision received July 14, 1987.
  • Accepted July 14, 1987.
  • Copyright © 1988 by the American Diabetes Association

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January 1988, 37(1)
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Specific Immunity to Streptozocin: Cellular Requirements for Induction of Lymphoproliferation
Christiane Klinkhammer, Poly Popowa, Helga Gleichmann
Diabetes Jan 1988, 37 (1) 74-80; DOI: 10.2337/diab.37.1.74

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Specific Immunity to Streptozocin: Cellular Requirements for Induction of Lymphoproliferation
Christiane Klinkhammer, Poly Popowa, Helga Gleichmann
Diabetes Jan 1988, 37 (1) 74-80; DOI: 10.2337/diab.37.1.74
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