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Original Articles

Adenine Nucleotide Metabolism in Hearts of Diabetic Rats: Comparison to Diaphragm, Liver, and Kidney

  1. Ronald L Jenkins,
  2. Huey G McDaniel,
  3. Stanley Digerness,
  4. S Wayne Parrish and
  5. Richard L Ong
  1. Departments of Medicine and Surgery, University of Alabama at Birmingham, and the Veterans Administration Medical Center Birmingham, Alabama
  1. Address correspondence and reprint requests to Diabetes Research (151-G), VAMC, 700, 19th Street South, Birmingham, AL 35233.
Diabetes 1988 May; 37(5): 629-636. https://doi.org/10.2337/diab.37.5.629
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Abstract

High-performance liquid chromatography analysis of acid-extracted tissues revealed decreases of high-energy nucleotides and increases in low-energy nucleotides and metabolites in heart, diaphragm, and liver but not in kidneys of diabetic rats. In comparison with nondiabetic rats, the total adenine nucleotide content of diabetic rat heart and diaphragm but not liver decreased, indicating an increase in catabolism of AMP. Maximal initial rates of the AMP catabolic enzymes 5′-nucleotidase, adenosine deaminase, and AMP deaminase were elevated in the hearts of BB/Wistar and streptozocin-induced diabetic rats. Nucleotide salvage enzymes adenylosuccinate synthetase and adenylosuccinate lyase were elevated above normal in the diabetic heart, whereas hypoxanthine-guanine phosphoribosyl transferase was not altered. Cytosolic-to-mitochondrial ratios from maximal initial rates after correction for mitochondrial breakage were increased above controls in diabetic hearts for nucleoside diphosphokinase and aspartate aminotransferase. Nucleotide levels, degradation rates, and substrate compartmentation between cytosol and mitochondria are discussed in relation to concurrent diabetes.

  • Received December 30, 1986.
  • Revision received October 8, 1987.
  • Accepted October 8, 1987.
  • Copyright © 1988 by the American Diabetes Association

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May 1988, 37(5)
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Adenine Nucleotide Metabolism in Hearts of Diabetic Rats: Comparison to Diaphragm, Liver, and Kidney
Ronald L Jenkins, Huey G McDaniel, Stanley Digerness, S Wayne Parrish, Richard L Ong
Diabetes May 1988, 37 (5) 629-636; DOI: 10.2337/diab.37.5.629

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Adenine Nucleotide Metabolism in Hearts of Diabetic Rats: Comparison to Diaphragm, Liver, and Kidney
Ronald L Jenkins, Huey G McDaniel, Stanley Digerness, S Wayne Parrish, Richard L Ong
Diabetes May 1988, 37 (5) 629-636; DOI: 10.2337/diab.37.5.629
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