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Original Articles

Dendritic Cells and Scavenger Macrophages in Pancreatic Islets of Prediabetic BB Rats

  1. Hieronymus A M Voorbij,
  2. Pieter H M Jeucken,
  3. Peter J Kabel,
  4. Meeny De Haan and
  5. Hemmo A Drexhage
  1. Laboratory for Clinical Immunology, Department of Pathology, Free University Hospital Amsterdam, The Netherlands
  1. Address correspondence and reprint requests to Dr. H.A.M. Voorbij, Laboratory for Clinical Immunology, Free University Hospital, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Diabetes 1989 Dec; 38(12): 1623-1629. https://doi.org/10.2337/diab.38.12.1623
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Abstract

Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease whose notorious pathologic feature is insulitis accompanied by destruction of β-cells. In this morphological study, we examined the pancreatic events during the onset of diabetes in spontaneously diabetic BB/Organon rats. Dendritic cells were the first cells to accumulate around the islets, followed by lymphocytes. Scavenger macrophages and MHC class II-positive β-cells were only seen late in the disease. These observations suggest a role for antigen-presenting dendritic cells in the onset of the β-cell-specific autoimmune reaction and emphasize the necessity to distinguish between the several monocyte-macrophage subtypes in studies on the pathogenesis of IDDM.

  • Received May 18, 1989.
  • Revision received August 9, 1989.
  • Accepted August 9, 1989.
  • Copyright © 1989 by the American Diabetes Association

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December 1989, 38(12)
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Dendritic Cells and Scavenger Macrophages in Pancreatic Islets of Prediabetic BB Rats
Hieronymus A M Voorbij, Pieter H M Jeucken, Peter J Kabel, Meeny De Haan, Hemmo A Drexhage
Diabetes Dec 1989, 38 (12) 1623-1629; DOI: 10.2337/diab.38.12.1623

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Dendritic Cells and Scavenger Macrophages in Pancreatic Islets of Prediabetic BB Rats
Hieronymus A M Voorbij, Pieter H M Jeucken, Peter J Kabel, Meeny De Haan, Hemmo A Drexhage
Diabetes Dec 1989, 38 (12) 1623-1629; DOI: 10.2337/diab.38.12.1623
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