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Original Articles

Cell Surface Alteration in Epstein-Barr Virus-Transformed Cells From Patients With Extreme Insulin Resistance

  1. D Lee Gorden,
  2. A Robert,
  3. Victoria Y Moncada,
  4. Simeon I Taylor,
  5. J Mühlhauser and
  6. Jean-Louis Carpentier
  1. Institute of Histology and Embryology, University of Geneva School of Medicine Geneva, Switzerland Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Bethesda, Maryland Vanderbilt University School of Medicine Nashville, Tennessee East Virginia Medical School Norfolk, Virginia
  1. Address correspondence and reprint requests to Dr. Jean-Louis Carpentier, Institute of Histology and Embryology, University of Geneva School of Medicine, 1211 Geneva 4, Switzerland.
Diabetes 1990 Aug; 39(8): 924-927. https://doi.org/10.2337/diab.39.8.924
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Abstract

An abnormality was detected in the morphology of the cell surface of Epstein-Barr virus-transformed lymphocytes of patients with genetic forms of insulin resistance. In cells from two patients with leprechaunism and two patients with type A extreme insulin resistance, scanning electron microscopy demonstrated a decrease in the percentage of the cell surface occupied by microvilli in cells from the patients with leprechaunism and type A insulin resistance compared with control cells. When cells from a healthy control subject and one of the patients with leprechaunism (Lep/Ark-1) were incubated with 125I-labeled insulin, there was a decrease in the percentage of 125I-insulin associated with microvilli on the cell surface. Thus, the decreased localization of insulin receptors with the microvillous region of the cell surface was in proportion to the decrease in microvilli.

  • Received November 3, 1989.
  • Revision received April 6, 1990.
  • Accepted April 6, 1990.
  • Copyright © 1990 by the American Diabetes Association

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August 1990, 39(8)
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Cell Surface Alteration in Epstein-Barr Virus-Transformed Cells From Patients With Extreme Insulin Resistance
D Lee Gorden, A Robert, Victoria Y Moncada, Simeon I Taylor, J Mühlhauser, Jean-Louis Carpentier
Diabetes Aug 1990, 39 (8) 924-927; DOI: 10.2337/diab.39.8.924

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Cell Surface Alteration in Epstein-Barr Virus-Transformed Cells From Patients With Extreme Insulin Resistance
D Lee Gorden, A Robert, Victoria Y Moncada, Simeon I Taylor, J Mühlhauser, Jean-Louis Carpentier
Diabetes Aug 1990, 39 (8) 924-927; DOI: 10.2337/diab.39.8.924
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© 2021 by the American Diabetes Association. Diabetes Print ISSN: 0012-1797, Online ISSN: 1939-327X.