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Original Articles

Differential Regulation of Glycosylated Phosphatidylinositol Subtypes by Insulin

  1. Glen N Gaulton
  1. Department of Pathology and Laboratory Medicine, Division of Immunobiology, University of Pennsylvania School of Medicine Philadelphia, Pennsylvania
  1. Address correspondence and reprint requests to Dr. Glen N. Gaulton, Department of Pathology and Laboratory Medicine, Division of Immunobiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104.
Diabetes 1991 Oct; 40(10): 1297-1304. https://doi.org/10.2337/diab.40.10.1297
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Abstract

Glycosylated phosphatidylinositol (gly-Pl) molecules have been implicated as precursors for insulin-sensitive second messengers (1–4) and lipid-anchored membrane proteins (5–9). The relationship between the diverse functions of these lipids and their predicted structural heterogeneity within gly-Pl subtypes was examined in human T lymphocytes. Four subtypes of gly-Pl molecules were identified in T lymphocytes after separation over high-performance thin-layer chromatography by sensitivity to Pl-specific phospholipase C and nitrous acid. Antibody probes of the glycan domain of gly-Pl were developed and used to assess the partial sensitivity of gly-Pl to insulin action. This analysis showed that the effects of insulin are linked to differential utilization of only two of the four gly-Pl subtypes in T lymphocytes. Polar fragments of this reaction were identified in extracellular supernatants from insulin-treated cells. The biological significance of insulin-dependent gly-Pl hydrolysis was demonstrated by insulin and inositol phosphoglycan regulation of glucose metabolism in intact lymphocytes. These results support the hypothesis that multifunctional roles of gly-Pl are served by discrete gly-Pl populations and that metabolites of gly-Pl subsets participate as signaling elements in insulin action.

  • Received August 13, 1990.
  • Revision received March 28, 1991.
  • Accepted March 28, 1991.
  • Copyright © 1991 by the American Diabetes Association

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October 1991, 40(10)
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Differential Regulation of Glycosylated Phosphatidylinositol Subtypes by Insulin
Glen N Gaulton
Diabetes Oct 1991, 40 (10) 1297-1304; DOI: 10.2337/diab.40.10.1297

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Differential Regulation of Glycosylated Phosphatidylinositol Subtypes by Insulin
Glen N Gaulton
Diabetes Oct 1991, 40 (10) 1297-1304; DOI: 10.2337/diab.40.10.1297
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