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Original Articles

Effects of Lipid on Basal Carbohydrate Metabolism in Normal Men

  1. Guenther Boden and
  2. Fayegh Jadali
  1. Department of Medicine, Division of Endocrinology and Metabolism, and the General Clinical Research Center, Temple University School of Medicine Philadelphia, Pennsylvania
  1. Address correspondence and reprint requests to Guenther Boden, MD, Temple University Health Sciences Center, 3401 North Broad Street, Philadelphia, PA 19104.
Diabetes 1991 Jun; 40(6): 686-692. https://doi.org/10.2337/diab.40.6.686
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Abstract

We investigated the effects of infusion of a 20% triglyceride emulsion plus heparin (LH) on carbohydrate (CHO) metabolism during basal insulin and glucose turnover conditions in normal male subjects. In study 1, LH or saline was infused at 0.5 and 1.5 ml/min for 2 h each. Plasma free fatty acids rose from ∼0.4 to 0.8 mM with the low rate and to between 1.6 and 2.1 mM with the high rate. Similar increases occurred in plasma concentrations of glycerol, acetoacetate, and β-hydroxybutyrate. LH infusions resulted in significant increases in C-peptide concentrations but had no effects on any of the other measured parameters of CHO metabolism. In study 2, LH or saline was infused as in study 1, but the compensatory insulin release was prevented by intravenous infusion of somatostatin and replacement of basal insulin and glucagon concentrations. This resulted in significant increases in plasma glucose (from 4.5 ± 0.2 to 7.1 ± 0.6 mM, P < 0.001) and hepatic glucose output (from 9.0 ± 1.5 to 11.3 ± 1.4 μmol · kg−1 · min−1, P < 0.05) and a decrease in glucose clearance (from 2.32 ± 0.13 to 1.44 ± 0.11 ml · kg−1 · min−1, P < 0.05). We conclude that lipids can have adverse effects on CHO metabolism under basal conditions and that healthy individuals can compensate for these effects with additional secretion of insulin.

  • Received June 8, 1990.
  • Revision received January 18, 1991.
  • Accepted January 18, 1991.
  • Copyright © 1991 by the American Diabetes Association
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June 1991, 40(6)
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Effects of Lipid on Basal Carbohydrate Metabolism in Normal Men
Guenther Boden, Fayegh Jadali
Diabetes Jun 1991, 40 (6) 686-692; DOI: 10.2337/diab.40.6.686

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Effects of Lipid on Basal Carbohydrate Metabolism in Normal Men
Guenther Boden, Fayegh Jadali
Diabetes Jun 1991, 40 (6) 686-692; DOI: 10.2337/diab.40.6.686
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