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Original Contributions

Beneficial Influence of Glycemic Control Upon the Growth and Function of Transplanted Islets

  1. Jyuhn-Huarng Juang,
  2. Susan Bonner-Weir,
  3. Ying-Jian Wu and
  4. Gordon C Weir
  1. Research Division, Joslin Diabetes Center, and Departments of Medicine, New England Deaconess Hospital and Brigham and Women's Hospital, Harvard Medical School Boston, Massachusetts
  1. Address correspondence and reprint requests to Dr. Jyuhn-Huarng Juang, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215.
Diabetes 1994 Nov; 43(11): 1334-1339. https://doi.org/10.2337/diab.43.11.1334
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Abstract

Syngeneic transplantation of 200 mouse islets under the kidney capsule usually fails to cure streptozocin-induced diabetes. We hypothesized that this number of islets, if engrafted in a normoglycemic environment, could expand their mass and improve their function to restore normoglycemia. Therefore, 200 freshly isolated mouse islets were transplanted under the capsule of each kidney of diabetic mice. Two weeks after transplantation, the recipients were normoglycemic, and one of the two grafts was removed. Removal of the graft was followed by transient hyperglycemia. At day 14 after graft removal, the β-cell mass and insulin content of the remaining graft had increased 2.3- and 2.1-fold, respectively. At day 3 after graft removal, the replication rate of β-cells increased threefold, and the mean individual β-cell crosssectional area, an indicator of cell size, was also increased. Perfusion of the kidney bearing the remaining graft showed biphasic insulin responses to high glucose and arginine 14 days after one graft removal. These data indicate that maintaining a period of near-normoglycemia after islet transplantation enhances the performance of an islet graft that would otherwise be expected to fail.

  • Received April 27, 1994.
  • Revision received July 8, 1994.
  • Accepted July 8, 1994.
  • Copyright © 1994 by the American Diabetes Association

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November 1994, 43(11)
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Beneficial Influence of Glycemic Control Upon the Growth and Function of Transplanted Islets
Jyuhn-Huarng Juang, Susan Bonner-Weir, Ying-Jian Wu, Gordon C Weir
Diabetes Nov 1994, 43 (11) 1334-1339; DOI: 10.2337/diab.43.11.1334

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Beneficial Influence of Glycemic Control Upon the Growth and Function of Transplanted Islets
Jyuhn-Huarng Juang, Susan Bonner-Weir, Ying-Jian Wu, Gordon C Weir
Diabetes Nov 1994, 43 (11) 1334-1339; DOI: 10.2337/diab.43.11.1334
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More in this TOC Section

  • Effect of Hyperketonemia and Hyperlacticacidemia on Symptoms, Cognitive Dysfunction, and Counterregulatory Hormone Responses During Hypoglycemia in Normal Humans
  • HLA-DQ-Restricted, Islet-Specific T-Cell Clones of a Type I Diabetic Patient: T-Cell Receptor Sequence Similarities to Insulitis-Inducing T-Cells of Nonobese Diabetic Mice
  • STZ Transport and Cytotoxicity: Specific Enhancement in GLUT2-Expressing Cells
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