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Original Articles

Higher Maternal Than Paternal Inheritance of Diabetes in GK Rats

  1. Dominique Gauguier,
  2. Isabelle Nelson,
  3. Catherine Bernard,
  4. Véronique Parent,
  5. Cécile Marsac,
  6. Daniel Cohen and
  7. Philippe Froguel
  1. Human Polymorphism Study Center Paris
  2. INSERM U75 Paris
  3. INSERM U358, St. Louis Hospital Paris, France
  1. Address correspondence and reprint requests to Dr. Dominique Gauguier, CEPH, 27 rue Juliette Dodu, 75010 Paris, France.
Diabetes 1994 Feb; 43(2): 220-224. https://doi.org/10.2337/diab.43.2.220
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Abstract

Results from crosses between Goto-Kakizaki (GK) rats, which exhibit spontaneous non-insulin-dependent diabetes mellitus (NIDDM), and outbred nondiabetic Wistar rats have demonstrated an effect of maternal inheritance on diabetes in offspring of the first generation (F1). At 6 weeks of age, F1 offspring of sex-directed crosses exhibited plasma glucose values intermediate between GK and Wistar parents. Hyperglycemia in F1 rats born of female GK rats (F1GK) was more marked than in those born of female Wistar (F1W) rats. At 3 months of age, F1 rats showed a marked impairment of both glucose tolerance and insulin secretion, which was intermediate between GK and Wistar rats. Glucose intolerance was more pronounced in F1GK rats than in F1W. By contrast, insulin secretion in F1W rats was more deteriorated than in F1GK rats. No deletion in mitochondrial DNA was observed in the GK rats, which decreased the possibility of a mitochondrial inheritance effect as an explanation of our findings. These data support a polygenic model in diabetes inheritance of NIDDM and suggest that, in addition to genetic factors, a perturbed maternal metabolism can contribute to its inheritance.

  • Received June 2, 1993.
  • Revision received September 9, 1993.
  • Accepted September 9, 1993.
  • Copyright © 1994 by the American Diabetes Association

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February 1994, 43(2)
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Higher Maternal Than Paternal Inheritance of Diabetes in GK Rats
Dominique Gauguier, Isabelle Nelson, Catherine Bernard, Véronique Parent, Cécile Marsac, Daniel Cohen, Philippe Froguel
Diabetes Feb 1994, 43 (2) 220-224; DOI: 10.2337/diab.43.2.220

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Higher Maternal Than Paternal Inheritance of Diabetes in GK Rats
Dominique Gauguier, Isabelle Nelson, Catherine Bernard, Véronique Parent, Cécile Marsac, Daniel Cohen, Philippe Froguel
Diabetes Feb 1994, 43 (2) 220-224; DOI: 10.2337/diab.43.2.220
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