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Rapid Publications

β2-Microglobulin–Deficient NOD Mice Do Not Develop Insulitis or Diabetes

  1. Linda S Wicker,
  2. Edward H Leiter,
  3. John A Todd,
  4. Robert J Renjilian,
  5. Erin Peterson,
  6. Paul A Fischer,
  7. Patricia L Podolin,
  8. Maarten Zijlstra,
  9. Rudolf Jaenisch and
  10. Laurence B Peterson
  1. Departments of Autoimmune Diseases Research, Merck Research Laboratories Rahway, New Jersey
  2. Cellular and Molecular Pharmacology, Merck Research Laboratories Rahway, New Jersey
  3. Immunology Research, Merck Research Laboratories Rahway, New Jersey
  4. The Jackson Laboratory Bar Harbor, Maine
  5. Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital Headington, Oxford, United Kingdom
  6. Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology Cambridge, Massachusetts
  1. Address correspondence and reprint requests to Dr. Linda Wicker or Dr. Larry Peterson, Merck Research Laboratories, Mail Code R80W-107, P.O. Box 2000, Rahway, NJ 07065-0900.
Diabetes 1994 Mar; 43(3): 500-504. https://doi.org/10.2337/diab.43.3.500
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Abstract

The role of CD8+ T-cells in the development of diabetes in the nonobese diabetic (NOD) mouse remains controversial. Although it is widely agreed that class II-restricted CD4+ T-cells are essential for the development of diabetes in the NOD model, some studies have suggested that CD8+ T-cells are not required for β-cell destruction. To assess the contribution of CD8+ T-cells to diabetes, we have developed a class of NOD mouse that lacks expression of βxs2-microglobulin (NOD-B2mnull). NOD-B2mnull mice, which lack both class I expression and CD8+ T-cells in the periphery, not only failed to develop diabetes but were completely devoid of insulitis. These results demonstrate an essential role for CD8+ T-cells in the initiation of the autoimmune response to β-cells in the NOD mouse.

  • Received November 1, 1993.
  • Revision received November 17, 1993.
  • Accepted November 17, 1993.
  • Copyright © 1994 by the American Diabetes Association
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March 1994, 43(3)
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β2-Microglobulin–Deficient NOD Mice Do Not Develop Insulitis or Diabetes
Linda S Wicker, Edward H Leiter, John A Todd, Robert J Renjilian, Erin Peterson, Paul A Fischer, Patricia L Podolin, Maarten Zijlstra, Rudolf Jaenisch, Laurence B Peterson
Diabetes Mar 1994, 43 (3) 500-504; DOI: 10.2337/diab.43.3.500

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β2-Microglobulin–Deficient NOD Mice Do Not Develop Insulitis or Diabetes
Linda S Wicker, Edward H Leiter, John A Todd, Robert J Renjilian, Erin Peterson, Paul A Fischer, Patricia L Podolin, Maarten Zijlstra, Rudolf Jaenisch, Laurence B Peterson
Diabetes Mar 1994, 43 (3) 500-504; DOI: 10.2337/diab.43.3.500
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