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Perspectives in Diabetes

Preventing Non-Insulin-Dependent Diabetes

  1. William C Knowler,
  2. K M V Narayan,
  3. Robert L Hanson,
  4. Robert G Nelson,
  5. Peter H Bennett,
  6. Jaakko Tuomilehto,
  7. Bengt Scherstén and
  8. David J Pettitt
  1. National Institute of Diabetes and Digestive and Kidney Diseases Phoenix, Arizona
  2. National Public Health Institute Helsinki, Finland
  3. Lund University Lund, Sweden
  1. Address correspondence to Dr. William C. Knowler, 1550 E. Indian School Rd., Phoenix, AZ 85014.
Diabetes 1995 May; 44(5): 483-488. https://doi.org/10.2337/diab.44.5.483
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Abstract

Many risk factors for non-insulin-dependent diabetes mellitus (NIDDM), such as obesity, physical inactivity, and high-fat diet, can potentially be modified. Furthermore, some of the metabolic abnormalities, such as insulin resistance and impaired glucose tolerance, that predict diabetes can be improved by behavior modification and drug treatment. Thus, at least to some extent, NIDDM may be preventable. Several small clinical trials have addressed the hypothesis that NIDDM can be prevented by dietary modification, physical activity, or drug treatment. Some studies suggest a preventive effect, but the conclusions are limited by considerations of sample size, randomization, or intensity of the interventions. Consequently, the hypothesis that NIDDM is preventable requires further testing.

  • Received September 23, 1994.
  • Revision received January 19, 1995.
  • Accepted January 19, 1995.
  • Copyright © 1995 by the American Diabetes Association

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May 1995, 44(5)
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Preventing Non-Insulin-Dependent Diabetes
William C Knowler, K M V Narayan, Robert L Hanson, Robert G Nelson, Peter H Bennett, Jaakko Tuomilehto, Bengt Scherstén, David J Pettitt
Diabetes May 1995, 44 (5) 483-488; DOI: 10.2337/diab.44.5.483

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Preventing Non-Insulin-Dependent Diabetes
William C Knowler, K M V Narayan, Robert L Hanson, Robert G Nelson, Peter H Bennett, Jaakko Tuomilehto, Bengt Scherstén, David J Pettitt
Diabetes May 1995, 44 (5) 483-488; DOI: 10.2337/diab.44.5.483
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