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Original Articles

Hyperglycemia-Induced Thrombin Formation in Diabetes: The Possible Role of Oxidative Stress

  1. Antonio Ceriello,
  2. Roberta Giacomello,
  3. Giuliana Stel,
  4. Enrico Motz,
  5. Claudio Taboga,
  6. Laura Tonutti,
  7. Mario Pirisi,
  8. Edmondo Falleti and
  9. Ettore Bartoli
  1. Department of Clinical and Experimental Pathology and Medicine, Chair of Internal Medicine Udine, Italy
  2. Chair of Clinical Pathology, University of Udine Udine, Italy
  3. Diabetes Unit, Udine General Hospital Udine, Italy
  1. Address correspondence and reprint requests to Dr. Antonio Ceriello, Department of Clinical and Experimental Pathology and Medicine, University of Udine, Chair of Internal Medicine, P.le S. Maria della Misericordia, I-33100 Udine, Italy.
Diabetes 1995 Aug; 44(8): 924-928. https://doi.org/10.2337/diab.44.8.924
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Abstract

Diabetes is characterized by the existence of a thrombosis-prone condition, possibly related to hyperglycemia. However, the mechanism linking hyperglycemia to the activation of the coagulation cascade is still unclear. It has been recently suggested that diabetes is accompanied by increased oxidative stress. In this work, the possibility that oxidative stress may be involved in the hyperglycemia-induced coagulation activation has been evaluated. Prothrombin fragment 1 + 2 (F1+2), which represents a reliable marker of the amount of thrombin released in the circulation, has been chosen for studying thrombin formation in vivo. In nine type II diabetic patients and in seven healthy control subjects, matched for age and body mass index, three different experiments were performed: oral glucose tolerance test (OGTT), intravenous antioxidant glutathione (GSH) administration for 2 h, and OGTT plus intravenous GSH administration. Samples were drawn at −15 min and every 30 min from 0 to 180 min. During the OGTT, F1+2 significantly increased in both diabetic and healthy subjects. GSH administration during OGTT normalized this phenomenon. GSH administered alone significantly decreased F1+2 in diabetic patients, while no effect was observed in the normal subjects. These data suggest that hyperglycemia may induce thrombin activation, possibly inducing an oxidative stress, and that antioxidant GSH may counterbalance this effect.

  • Received March 29, 1994.
  • Revision received April 13, 1995.
  • Accepted April 13, 1995.
  • Copyright © 1995 by the American Diabetes Association

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August 1995, 44(8)
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Hyperglycemia-Induced Thrombin Formation in Diabetes: The Possible Role of Oxidative Stress
Antonio Ceriello, Roberta Giacomello, Giuliana Stel, Enrico Motz, Claudio Taboga, Laura Tonutti, Mario Pirisi, Edmondo Falleti, Ettore Bartoli
Diabetes Aug 1995, 44 (8) 924-928; DOI: 10.2337/diab.44.8.924

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Hyperglycemia-Induced Thrombin Formation in Diabetes: The Possible Role of Oxidative Stress
Antonio Ceriello, Roberta Giacomello, Giuliana Stel, Enrico Motz, Claudio Taboga, Laura Tonutti, Mario Pirisi, Edmondo Falleti, Ettore Bartoli
Diabetes Aug 1995, 44 (8) 924-928; DOI: 10.2337/diab.44.8.924
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