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Original Articles

Improvement of Insulin Action in Diabetic Transgenic Mice Selectively Overexpressing GLUT4 in Skeletal Muscle

  1. Armelle Leturque,
  2. Martine Loizeau,
  3. Sophie Vaulont,
  4. Marjo Salminen and
  5. Jean Girard
  1. Centre de Recherche sur I'Endocrinologie Moléeculaire et le Développement, Centre National de la Recherche Scientifique Meudon-Bellevue, France
  2. Institut Cochin de Génétique Moléculaire, Institute National de la Sante de la Recherche Medicale U129, Paris, France
  1. Address correspondence and reprint requests to Dr. Armelle Leturque, CEREMOD, CNRS, 9 rue Jules Hetzel, 92190 Meudon-Bellevue, France
Diabetes 1996 Jan; 45(1): 23-27. https://doi.org/10.2337/diab.45.1.23
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Abstract

To investigate the role of glucose transporter expression in whole-body glucose homeostasis, we have created transgenic mice that have a 2.0- to 3.5-fold increase in GLUT4 glucose transporter level in skeletal muscle and heart. This increase is sufficient to significantly improve insulin action and to reduce basal blood glucose levels in transgenic streptozotocin-induced diabetic mice. These results provide the first evidence of a direct causality between skeletal muscle GLUT4 transporter level and overall insulin responsiveness.

  • Received May 5, 1995.
  • Received August 24, 1995.
  • Accepted August 24, 1995.
  • Copyright © 1996 by the American Diabetes Association
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January 1996, 45(1)
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Improvement of Insulin Action in Diabetic Transgenic Mice Selectively Overexpressing GLUT4 in Skeletal Muscle
Armelle Leturque, Martine Loizeau, Sophie Vaulont, Marjo Salminen, Jean Girard
Diabetes Jan 1996, 45 (1) 23-27; DOI: 10.2337/diab.45.1.23

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Improvement of Insulin Action in Diabetic Transgenic Mice Selectively Overexpressing GLUT4 in Skeletal Muscle
Armelle Leturque, Martine Loizeau, Sophie Vaulont, Marjo Salminen, Jean Girard
Diabetes Jan 1996, 45 (1) 23-27; DOI: 10.2337/diab.45.1.23
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