Neutralization of TGF-β by Anti-TGF-β Antibody Attenuates Kidney Hypertrophy and the Enhanced Extracellular Matrix Gene Expression in STZ-Induced Diabetic Mice

Kumar Sharma; Yulin Jin; Jia Guo; Fuad N Ziyadeh

doi:10.2337/diab.45.4.522

Original Articles

Neutralization of TGF-β by Anti-TGF-β Antibody Attenuates Kidney Hypertrophy and the Enhanced Extracellular Matrix Gene Expression in STZ-Induced Diabetic Mice

Kumar Sharma,
Yulin Jin,
Jia Guo and
Fuad N Ziyadeh

Renal-Electrolyte and Hypertension Division and Penn Center for Molecular Studies of Kidney Diseases, Department of Medicine, University of Pennsylvania School of Medicine Philadelphia, Pennsylvania
Division of Nephrology, Department of Medicine, Thomas Jefferson University Philadelphia, Pennsylvania

Address correspondence and reprint requests to Dr. Fuad N. Ziyadeh, Renal-Electrolyte & Hypertension Division, 700 Clinical Research Building, University of Pennsylvania, 422 Curie Blvd., Philadelphia, PA 19104-6144.

Diabetes 1996 Apr; 45(4): 522-530. https://doi.org/10.2337/diab.45.4.522

Article Information

vol. 45 no. 4 522-530

DOI

https://doi.org/10.2337/diab.45.4.522

PubMed

8603776

Published By

American Diabetes Association

Print ISSN

0012-1797

Online ISSN

1939-327X

History

Received August 11, 1995
Revision received November 29, 1995
Accepted November 29, 1995
Published in print April 1, 1996.

Author Information

Kumar Sharma,
Yulin Jin,
Jia Guo and
Fuad N Ziyadeh

Renal-Electrolyte and Hypertension Division and Penn Center for Molecular Studies of Kidney Diseases, Department of Medicine, University of Pennsylvania School of Medicine Philadelphia, Pennsylvania
Division of Nephrology, Department of Medicine, Thomas Jefferson University Philadelphia, Pennsylvania

Address correspondence and reprint requests to Dr. Fuad N. Ziyadeh, Renal-Electrolyte & Hypertension Division, 700 Clinical Research Building, University of Pennsylvania, 422 Curie Blvd., Philadelphia, PA 19104-6144.

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