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Rapid Publications

Glucagon-Like Peptide I Receptors in the Subfornical Organ and the Area Postrema Are Accessible to Circulating Glucagon-Like Peptide I

  1. Cathrine Ørskov,
  2. Steen S Poulsen,
  3. Morten Mørten and
  4. Jens J Holst
  1. Departments of Medical Anatomy, The Panum Institute, University of Copenhagen Copenhagen, Denmark
  2. Medical Physiology, The Panum Institute, University of Copenhagen Copenhagen, Denmark
  1. Address correspondence and reprint requests to Dr. Cathrine Ørskov, Dept. of Medical Anatomy B, Panum Institute, Blegdamsvej 3c, 2200 Copenhagen N, Denmark.
Diabetes 1996 Jun; 45(6): 832-835. https://doi.org/10.2337/diab.45.6.832
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Abstract

The intestinal incretin hormone glucagon-like peptide I (GLP-I) inhibits gastric motility and secretion in normal, but not in vagotomized subjects, pointing to a centrally mediated effect. Therefore, our aim was to study the availability of rat brain GLP-I receptors to peripherally injected 125I-labeled GLP-I. The specificity of the binding was tested by co-injection of excess amounts of unlabeled GLP-I. Using light microscopical autoradiography of rat brain sections, we found specific 125I-GLP-I binding exclusively in the subfornical organ and the area postrema. This binding was abolished when an excess amount of unlabeled GLP-I was co-injected with the labeled GLP-I. We conclude that cells in the subfornical organ and the area postrema could be responsive to blood-borne GLP-I. The observed binding of peripherally administered GLP-I to the subfornical organ and the area postrema, which both have close neuroanatomical connections with hypothalamic areas involved in water and appetite homeostasis, is consistent with the potential roles of circulating GLP-I in the central regulation of appetite and autonomic functions.

  • Received February 28, 1996.
  • Accepted March 11, 1996.
  • Copyright © 1996 by the American Diabetes Association
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June 1996, 45(6)
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Glucagon-Like Peptide I Receptors in the Subfornical Organ and the Area Postrema Are Accessible to Circulating Glucagon-Like Peptide I
Cathrine Ørskov, Steen S Poulsen, Morten Mørten, Jens J Holst
Diabetes Jun 1996, 45 (6) 832-835; DOI: 10.2337/diab.45.6.832

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Glucagon-Like Peptide I Receptors in the Subfornical Organ and the Area Postrema Are Accessible to Circulating Glucagon-Like Peptide I
Cathrine Ørskov, Steen S Poulsen, Morten Mørten, Jens J Holst
Diabetes Jun 1996, 45 (6) 832-835; DOI: 10.2337/diab.45.6.832
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