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Brief Genetics Reports

Genetic Variation of the Heparan Sulfate Proteoglycan Gene (Perlecan Gene): Association With Urinary Albumin Excretion in IDDM Patients

  1. P M Hansen,
  2. T Chowdhury,
  3. T Deckert,
  4. A Hellgren,
  5. S C Bain and
  6. F Pociot
  1. Steno Diabetes Center Gentofte, Denmark
  2. University of Birmingham, Birmingham Heartlands Hospital Birmingham, U.K.
  1. Address correspondence and reprint requests to Dr. Flemming Pociot, Steno Diabetes Center, Niels Steensensvej 2, DK-2820 Gentofte, Denmark. E-mail: fpoc{at}novo.dk
Diabetes 1997 Oct; 46(10): 1658-1659. https://doi.org/10.2337/diacare.46.10.1658
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Abstract

Both in patients with IDDM (1) and in healthy control subjects (2,3), increased urinary albumin excretion rate (AER) is associated with high relative morbidity and mortality. In IDDM patients, genetic susceptibility factors are most likely contributing to an increased AER (4,5) resulting in a cumulative incidence of nephropathy (AER >300 mg/24 h) of -30% (6). So far, candidate genes, proposed as susceptibility markers linked to abnormal albuminuria, have been identified because of the knowledge of pathophysiological events related to diabetic nephropathy. Heparan sulfate proteoglycan (HSPG, i.e., Perlecan) constitutes an integrated part of the glomerular basement membrane. It consists of a central core protein to which anionie sulfated polysaccharide chains (heparan sulfate [HS]) are linked (7), thus contributing to the negative charge of the glomerular filtration barrier and thereby indirectly to the composition of the glomerular filtration product (8,9). In IDDM patients, it has been demonstrated that increased AER is reduced by the administration of heparin (10) most likely because of a stimulating effect on the HS synthesis (11).

  • Received January 13, 1997.
  • Revision received June 13, 1997.
  • Accepted June 13, 1997.
  • Copyright © 1997 by the American Diabetes Association
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October 1997, 46(10)
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Genetic Variation of the Heparan Sulfate Proteoglycan Gene (Perlecan Gene): Association With Urinary Albumin Excretion in IDDM Patients
P M Hansen, T Chowdhury, T Deckert, A Hellgren, S C Bain, F Pociot
Diabetes Oct 1997, 46 (10) 1658-1659; DOI: 10.2337/diacare.46.10.1658

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Genetic Variation of the Heparan Sulfate Proteoglycan Gene (Perlecan Gene): Association With Urinary Albumin Excretion in IDDM Patients
P M Hansen, T Chowdhury, T Deckert, A Hellgren, S C Bain, F Pociot
Diabetes Oct 1997, 46 (10) 1658-1659; DOI: 10.2337/diacare.46.10.1658
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