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Perspectives in Diabetes

Moving GLUT4: The Biogenesis and Trafficking of GLUT4 Storage Vesicles

  1. Shane Rea and
  2. David E James
  1. Centre for Molecular and Cellular Biology, University of Queensland St. Lucia, QLD 4072, Australia
  1. Address correspondence and reprint requests to Drs. Shane Rea and David E. James, Centre for Molecular and Cellular Biology, University of Queensland, St. Lucia, QLD 4072, Australia. E-mail: s.rea{at}cmcb.uq.edu.au or d.james{at}cmcb.uq.edu.au.
Diabetes 1997 Nov; 46(11): 1667-1677. https://doi.org/10.2337/diab.46.11.1667
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Abstract

The GLUT4 system in muscle and fat cells plays an important role in whole-body glucose homeostasis. Insulin stimulates the translocation of GLUT4 from an intracellular storage compartment to the cell surface. The nature of this compartment remains largely unknown. We review recent studies describing the biogenesis and molecular constituents of the GLUT4 storage compartment and conclude that it is segregated from the endosomal and biosynthetic pathways. Further, we present evidence to suggest that the GLUT4 storage compartment moves directly to the plasma membrane in response to insulin and, hence, is analogous to small synaptic vesicles in neurons. We propose that the GLUT4 storage compartment be referred to as GLUT4 storage vesicles or GSVs.

  • Received July 8, 1997.
  • Revision received August 4, 1997.
  • Accepted August 4, 1997.
  • Copyright © 1997 by the American Diabetes Association

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November 1997, 46(11)
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Moving GLUT4: The Biogenesis and Trafficking of GLUT4 Storage Vesicles
Shane Rea, David E James
Diabetes Nov 1997, 46 (11) 1667-1677; DOI: 10.2337/diab.46.11.1667

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Moving GLUT4: The Biogenesis and Trafficking of GLUT4 Storage Vesicles
Shane Rea, David E James
Diabetes Nov 1997, 46 (11) 1667-1677; DOI: 10.2337/diab.46.11.1667
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